摘要
为建立一种用于大肠癌早期筛检的指标，采用半乳糖氧化酶法检测了２４６例直肠粘液标本中的Ｔ抗原。其中３５例大肠癌患者的阳性检出率为８２．８％；８６例大肠息肉患者中肿瘤性息肉阳性率为４９．０％，炎性息肉阳性率为１４．２％；在７３例肠道慢性炎症患者中阳性率为１６．４％；在５０例大肠粘膜正常的患者中阳性率为８．０％。结果表明，用半乳糖氧化酶法检测Ｔ抗原对大肠癌的筛检具有较高的敏感性（８２．８％）和特异性（９２．０％），方法简便，重复性好，并且，也为大肠息肉的筛检及其恶变的监测提供了一种可供选择的方法。
he galactose oxidase method was employed to detect the β-D-Gal(1→3)-D-GalNAC residue ofT-antigen in large intestinal mucus of 246 subjects. The positive rates of the test were 82.8%, 49.0%,14.2%,16.4%,and 8.0%in the mucous sample obtained from 35 patients with large intesti-nal carcinomas,37 with tumorous polyp , 35 with inflammatory polyp,73 with chronic intestinal in-flammation,and 50 controls,respectively. The chi-square test demonstrated that there were signifi-cant differences between the groups of carcinoma and control(P<0.01),also polyp and control(P<0.01).The test had a high sensitivity (82.8%)and specificity(92.0%)in diagnosis of large in-testinal carcinomas and may be used as a practical mass screening test for large intestinal neoplasms.
