摘要
目的 :研究补肾中药密骨片预防老年男性骨质疏松的作用。方法 :将 4 4例老年男性受试者随机分为中药组和对照组。中药组服用补肾中药密骨片和钙剂 ,对照组只服用钙剂 ,均用药 1年。研究开始和结束时检测受试者腰椎和股骨上端骨密度 ,以及血清骨钙素 (s BGP)和尿羟脯氨酸与肌酐比值 (Hyp/Cr)。 结果 :均用药 1年后 ,中药组腰椎骨密度略有上升 (P >0 0 5 ) ,而股骨颈、Ward′s三角区和股骨粗隆骨密度则显著上升 (P <0 0 5 ) ;对照组各处骨密度均明显下降 (P <0 0 5 )。对照组s BGP和Hyp/Cr比值均上升 (P <0 0 5 ) ,而中药组则无显著变化。结论 :补肾中药密骨片可通过抑制骨转换而防止老年男性骨质丢失。
Objective: To study the bone loss preventive effect of Chinese drug for tonifying Shen, Migu Tablet (MGT), in aged males. Methods: Forty four aged males were randomly divided into the CDIK group treated with MGT and calcium preparation and the control group treated with calcium preparation alone. The therapeutic course for both group was 1 year. Bone mineral density (BMD) of lumbar vertebra and upper femur, serum osteocaicin (s BGP) and urinary oxyproline hydroxyproline/creatinine ratio (Hyp/Cr) were determined at the beginning and ending of the study. Results: After 12 months treatment, the BMD of lumbar vertebra increased slightly (P>0 05), while BMD of femoral neck, Ward′s triangular space and femoral trochanter increased significantly (P<0 05). But the BMD in different parts in the control group were all decreased significantly. Moreover, s BGP and Hyp/Cr ratio were all raised in the control group but unchanged in the treated group. Conclusion: Chinese drugs for tonifying Shen, MGT could prevent bone loss in aged males through inhibiting bone turn over.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2003年第1期4-6,共3页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
临床研究
补肾中药
骨密度
骨钙素
老年男性
骨丢失
药理
Chinese drugs for tonifying Shen, bone mineral density, osteocalcin, aged males, bone loss
