摘要
AIM: To investigate the changes of monoami ne oxidase (MAO), glutathione peroxidase(GSH-Px), superoxide dismutase (SOD ), and malondialdehyde (MDA) in the kidneys of rats exposed to 8 Hz, 130 dB i nfrasound at different times, and to explore the mechanism of kidney injury caus ed by infrasound. METHODS : Thirty-five male SD rats were random ly divided into five groups. Group 1 served as control group, and group 2 to gro up 5 were exposed 2 hours per day to 8 Hz 130 dB infrasound for 1 wk, 2 wk, 3 wk and 4 wk, respectively. RESULTS: MAO activities in all the inf rasound exposed groups increased [(97±28～108±8) nkat·g -1 ], but they s howed no significant difference (P>0 05). GSH-Px activ ities in 4 wk group increased significantly [(181±34～228±24) nkat·g -1 ,[WTBX] P<0 05]. SOD activities remained unchanged followin g exposure to infrasound (. SOD activities remained unchanged followin g exposure to infrasound (P>0 05). MDA concentration i n the 1 wk and 2 wk groups increased significantly[(1 93±0 49～2 55±0 51) μmol·g -1 ,[WTBX]P<0 05], , and it returned to the cont rol level in the 3 wk and 4 wk(1 93±0 49～1 87±0 26)μmol· g -1 . CONCLUSION: The results suggest that the lipid peroxidati on in the kidneys of infrasound exposed rats can be increased and infrasound may play an important role in kidney injury.
AIM: To investigate the changes of monoami ne oxidase (MAO), glutathione peroxidase(GSH-Px), superoxide dismutase (SOD ), and malondialdehyde (MDA) in the kidneys of rats exposed to 8 Hz, 130 dB i nfrasound at different times, and to explore the mechanism of kidney injury caus ed by infrasound. METHODS : Thirty-five male SD rats were random ly divided into five groups. Group 1 served as control group, and group 2 to gro up 5 were exposed 2 hours per day to 8 Hz 130 dB infrasound for 1 wk, 2 wk, 3 wk and 4 wk, respectively. RESULTS: MAO activities in all the inf rasound exposed groups increased [(97±28～108±8) nkat·g -1 ], but they s howed no significant difference (P>0 05). GSH-Px activ ities in 4 wk group increased significantly [(181±34～228±24) nkat·g -1 ,[WTBX] P<0 05]. SOD activities remained unchanged followin g exposure to infrasound (. SOD activities remained unchanged followin g exposure to infrasound (P>0 05). MDA concentration i n the 1 wk and 2 wk groups increased significantly[(1 93±0 49～2 55±0 51) μmol·g -1 ,[WTBX]P<0 05], , and it returned to the cont rol level in the 3 wk and 4 wk(1 93±0 49～1 87±0 26)μmol· g -1 . CONCLUSION: The results suggest that the lipid peroxidati on in the kidneys of infrasound exposed rats can be increased and infrasound may play an important role in kidney injury.
出处
《第四军医大学学报》
北大核心
2003年第2期113-115,共3页
Journal of the Fourth Military Medical University
基金
全军重点课题之分题 (96Z0 4 2 )
关键词
次声
大鼠
肾脏
单胺氧化酶
GSH-PX
SOD
MDA
infrasound
monoamine oxidase
glutathio ne peroxidase
superoxide dismutase
malondialdehyde
kidney
rats
