摘要
为观察丙型肝炎病毒(HCV)感染者与健康人血清高密度脂蛋白胆固醇 (HDL C)、低密度脂蛋白胆固醇 (LDL C)、载脂蛋白B(apoB)、载脂蛋白C2 (apoC2 )、载脂蛋白C3(apoC3)、载脂蛋白E(apoE)及脂蛋白 (a) [LP(a) ]水平的差异 ,分别取健康人及HCV感染者血清各 75份 ,并对其进行检测。结果发现 ,HCV感染者血清中的HDL C、apoB及apoC3的含量均低于健康人 (P <0 0 5 ) ;LDL C、apoC2的含量亦低于健康人 ,但无统计学意义 (P >0 0 5 ) ;apoE及LP(a)的含量均高于健康人 (P<0 0 5 )。另外 ,HCVRNA及抗 HCV均阳性的患者血清中的HDL C、LDL C、apoB、apoC2、apoC3、apoE及LP(a)的含量与抗 HCV阳性但HCVRNA阴性者比较有差异 ,但无统计学意义(P >0 0 5 )。
To observe the difference in the concentration of the high density lipoprotein cholesterol (HDL C), low density lipoprotein cholesterol (LDL C),apolipoprotein B (apo B),C2 (apo C2),C3 (apo C3),E (apo E) and lipoprotein (a)(LP(a)) in sera obtained from the patients infected with HCV and the normal subjects. A total of 150 blood serum samples were obtained from 75 patients infected with HCV and 75 normal subjects (1-70 years of age). The proportion of sex and age between the HCV infected patients and the normal subjects were almost identical. We measured the contents of HDL C, LDL C, apo B, apo C2, apo C3, apo E and LP(a) in sera using 7070 chemistry analyzer and chemical preparations made in Japan. The differences in the HDL C,LDL C,apo B, apo C2, apo C3, apo E and LP(a) among the HCV infected patients and the normal subjects were statistically analyzed. In the patients, the mean concentration of the HDL C was 1 22 mmol/L, the LDL C was 119 7 mmol/L, the apo B was 882mg/L, the apo C2 was 15 3mg/L, the apo C3 was 59 6mg/L, the apo E was 52 4mg/L,the LP(a) was 201mg/L. In the normal subjects, the mean concentration of the HDL C was 1 39 mmol/L, the LDL C was 123 mmol/L, the apo B was 1031mg/L, the apo C2 was 16mg/L, the apo C3 was 79 1mg/L, the apo E was 40 1mg/L, the LP(a) was 100mg/L. The concentration of HDL C, apo B, apo C3 in the patients infected with HCV was significantly lower than that of normal subjects ( P <0 05); LDL C, apo C2 in the patients infected with HCV were also lower than that of normal subjects ( P >0 05); apo E, LP(a) in the patients infected with HCV was significantly higher than that of normal subjects ( P <0 05). In patients with HCV RNA positive, the apo AⅠand apo AⅡ levels were also different from that of HCV RNA negative, but there was no statistically significant difference.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2003年第1期58-60,共3页
Medical Journal of Chinese People's Liberation Army
