摘要
目的 :观察阿托伐他汀对异常脂蛋白血症病人的调脂效果。 方法 :39例异常脂蛋白血症病人随机分为 2组 :阿托伐他汀组 (2 1例 ,10 m g/d,po)与普伐他汀组 (18例 ,10 m g/d,po)。服药前与服药 6周后测定血脂水平。结果 :服药 6周后 ,阿托伐他汀组与普伐他汀组的血清总胆固醇 (TC)比用药前降低 ,降幅分别为 2 6 .7%与 19.4% (P<0 .0 1) ;血清低密度脂蛋白胆固醇 (L DL - C)也比用药前显著降低 ,降幅依次为 39.2 %与 2 4.2 % (P<0 .0 1) ;阿托伐他汀组血清三酰甘油 (TG)比用药前明显降低 ,降幅达 2 5 .3% (P<0 .0 1) ,而普伐他汀组血清 TG仅降低 4.1% (P>0 .0 5 ) ;两组血清高密度脂蛋白胆固醇 (HDL - C)比用药前有不同程度升高 ,阿托伐他汀组显著升高达 6 .4% (P<0 .0 5 ) ,普伐他汀组升高 4.8% (P>0 .0 5 )。结论 :阿托伐他汀能够显著降低异常脂蛋白血症病人的血清 TC、L DL - C与 TG水平 ,可有效地用于异常脂蛋白血症病人的调脂治疗。
Objective: To evaluate the effects of atorvastatin on lipid profile modification in patients with dyslipoproteinemia. Methods: Thirth-nine patients with dyslipoproteinemia were randomly divided into 2 groups, atorvastatin group (n=21, 10 mg/d, po) and pravastatin group(n=18, 10 mg/d, po). Blood samples were taken from forearm vein (after fasting for 12 h) before and 6 weeks after the treatment with the drugs for the analysis of serum lipid profile. Results:The effects of atorvastatin on lowering serum total cholesterol(TC) and low density lipoprotein cholesterol (LDL-C) were similar to those of pravastatin.The concentrations of TC and LDL-C decreased by 26.7% and 39.2% in atorvastatin group (P<0.01) and by 19.4% and 24.2% in pravastatin group(P<0.01), respectively, as compared with before treatment. Serum triglyceride(TG) in atorvastatin group was reduced by 25.3%(P<0.01), but in pravastatin group serum TG was only decreased by 4.1%(P>0.05). The high density lipoprotein cholesterol(HDL-C) in atorvastatin group was remarkably increased by 6.4%(P<0.05). Conclusion: Atorvastatin could greatly decrease TC,LDL-C and TG,and increase HDL-C in patients with dyslipoproteinemia,and can be effectively applied to the lipid profile modification of these patients.
出处
《药学服务与研究》
CAS
CSCD
2002年第4期224-226,共3页
Pharmaceutical Care and Research
