摘要
目的 观察亚临床癎样放电(SED)对大鼠情感行为及空间学习和记忆能力的影响。方法 通过不同脑区惊厥阈下电刺激,观测实验大鼠认知行为改变。结果 不同脑区电刺激停止后1d SED大鼠旷场活动性明显减少,3d海马阈下刺激组大鼠仍明显减少;1周内拒俘反应性均显著增强。大鼠Morris水迷宫逃避潜伏期明显延长,空间定向能力测试中重复阈下再刺激大鼠在水迷宫的四个象限中无目的漫游。结论 SED可引发实验大鼠活动习性改变、警觉水平增高、环境适应能力下降,以及短暂空间学习和记忆能力受损。
Objective To observe the effects of subclinical epileptiform discharges (SED) on cognitive behaviors and spatial learning and memory ability in rats. Methods The cognitive behavior and spatial learning ability of rats were tested after subconvulsive electrical stimulations at different regions of rat brain. Results The experimental rats with SED displayed substantial decreases in open-field activity for one day after poststimulation, and further reduced 3 days after the last stimulation in stimulated rats to hippocampus, as well as the resistance to capture increased significantly one week after stimulation. The mean escape latency for SED rats in spatial bias in the water maze training prolonged significantly. And in the spatial orientation test the SED rats following repeated stimulations swam aimlessly in the four -quadrant pool during the probe trial in the Morris water maze. Conclusions The SED rats displayed the significant abnormalities of cognitive behaviors as the substantial changes of behavioral habits, increased anxiety and defense, enhanced startle and delayed habituation to environment, and transitory spatial learning and memory impairment.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2003年第1期18-20,共3页
Journal of Applied Clinical Pediatrics
关键词
亚临床痫样放电
大鼠
认知行为
学习
记忆
epileptiform discharges
behavior
learning and memory
hippocampus
