摘要
目的 观察GBE与DSMO合用及单用对AD模型大鼠学习记忆的影响 ,了解DMSO是否具有抗AD的作用 ,以及与GBE合用是否有协同作用。方法 通过海马内注射Aβ2 5-3 5制备AD模型 ,连续灌胃给药 14d后 ,利用改良的Morris水迷宫方法 (空间探索及定向航行实验 )检测GBE与DMSO对大鼠的空间辨别学习记忆的影响 ;结果 在定向航行实验中 ,给药组大鼠在原安全岛所在象限的搜索时间和距离均较Aβ组延长。GBE与DMSO合用组大鼠的成绩与单用组比较无差异。 结论 GBE及DMSO可以改善Aβ2 5-3 5所致的AD模型大鼠的学习记忆障碍。在本实验条件所用的剂量下 ,GBE与DMSO合用未见明显的协同作用。
Objective To observe the effects of Ginkgo Biloba Extract (GBE) and Dimethyl Sulfoxide (DMSO) on the learning and memory dysfunctions of the Alzheimer's disease(AD) model rats. To explore whether there is a synergetic effect between GBE and DMSO on this model. Methods GBE and DMSO had been administrated for fourteen days to AD model rats induced by microinjecting β amyloid peptide segment 25 35 (Aβ 25 35 ) into hippocampus. Reformative Morris water maze task including place navigation test and spatial probe test was used for behavior test after administration. Results During place navigation test, the mean escape latency and searching distance were decreased in drug treated groups compared with Aβ group. While in the spatial probe test, the mean searching distance and time were increased accordingly. No significant synergetic effect of GBE combined with DMSO on the place navigation and spatial probe test observed. Conclusions Both GBE and DMSO can improve learning and memory functions of rats induced by Aβ 25 35 . No significant synergic effect was observed between GBE and DMSO at dose in present experiment.[
出处
《合肥医学院学报》
2002年第6期485-488,共4页
Journal of Zunyi Medical University
基金
ProjectsupportedbyNaturalScienceFunda tionofGuizhouProvince
№ (2 0 0 0 ) 30 4 4 .
