摘要
转化生长因子 β(TGFβ)超家族作为一组作用广泛的细胞因子对原始生殖细胞 (PGC)及生殖母细胞的发育过程也具有调节作用。该超家族中的TGFβ、骨形态形成蛋白 (BMP)、活化素、抑制素以及抗M櫣ｌｌｅｒ管激素 (AMH)均在雄性生殖细胞的发育中发挥重要作用 ,其下游分子Smads蛋白参与了部分成员的信号转导。此外 ,TGFβ和AMH还对生殖细胞发育过程中的凋亡具有促进作用。
Transforming growth factor β (TGFβ) superfamily can regulate the development of primordial germ cell (PGC) and gonocyte. TGFβ, bone morphogenetic protein (BMP), activin, inhibin ,and anti Müllerian hormone (AMH), all of which belong to the TGFβ superfamily, can play important roles in male germ cell development. Their downstream signaling molecules, Smads proteins are involved in the signal transduction pathway. In addition, TGFβ and AMH contribute to the apoptosis during development. Understanding this effect will help to elucidate the molecular mechanism of the early development of male reproductive system and the pathogenesis of testicular cancer.
出处
《中华男科学杂志》
CAS
CSCD
2002年第6期435-437,共3页
National Journal of Andrology
基金
国家自然科学基金资助项目 (3 9870 10 9)
全军医药卫生科研基金资助项目 (98M 10 60 1MA183 )
