摘要
局部染色质重塑是多种增殖分化相关基因表达的重要调控机制 ,组蛋白乙酰化酶和去乙酰化酶是参与该调控机制的两种关键酶。研究表明 ,多种白血病基因异常是通过直接影响参与染色质修饰的蛋白酶而发挥致病作用的 。
Local remodeling of chromatin is a key step in the transcriptional activation of genes. The studies have shown that the proteins that regulate the modification of chromatin are themselves disrupted in many leukemic chromosomal rearrangements. Pharmacological manipulation of chromatin remodeling might develop into a potent and specific strategy for the treatment of these leukemias
出处
《医学研究生学报》
CAS
2002年第6期531-533,共3页
Journal of Medical Postgraduates
基金
军队"十五"医学科研面上资助课题 (批准号 :0 1MB0 2 1)
