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组蛋白乙酰化酶和去乙酰化酶在细胞增生分化和肿瘤发生中的作用 被引量：5

Roles of histone acetyltransferases and deacetylases in the process of cell proliferation,differentiation and tumorogenesis
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摘要 真核细胞组蛋白 N端赖氨酸残基的乙酰化与基因的转录激活有关。多种具有组蛋白乙酰化酶 (HAT)和组蛋白去乙酰化酶 (HDAC)活性的调节因子 ,通过对组蛋白乙酰化过程的调节 ,在基因表达调控中发挥着重要作用。HAT和 Acetylation of lysine residues of core histone N terminal domains has been found correlatively associated with transcriptional activation in eukaryotes. Recent studies showed that some transcriptional regulators with histone acetyltransferase(HAT) and deacetylase(HDAC) activities may play a causative role in regulating gene expression. The link between tumorigenic processes and misregulated or mistargeted HAT and HDAC activities has been reported.
作者 于亚平 王学文
机构地区 南京军区南京总医院血液科
出处 《医学研究生学报》 CAS 2001年第3期249-251,共3页 Journal of Medical Postgraduates
关键词 组蛋白乙酰化酶 组蛋白去乙酰化酶 细胞增生 肿瘤 Histone acetyltransferase Histone deacetylase Cell proliferation, differentiation Tumor
分类号 R730.2 [医药卫生—肿瘤]
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参考文献25

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同被引文献38

  • 1谢爱华,廖晨钟,李伯玉,山松,邓沱,李志斌,宁志强,胡伟明,石乐明,周家驹,鲁先平.以组蛋白去乙酰化酶为靶标的抗癌药物研发进展[J].中国新药杂志,2005,14(1):10-14. 被引量：8
  • 2王生余,张旭辉,于晓妉.新型抗肿瘤药物组蛋白去乙酰化酶抑制剂[J].国际肿瘤学杂志,2006,33(6):404-406. 被引量：12
  • 3NELSON S M,FERGUSON L R,DENNY W A.DNA and the chromosome-varied targets for chemotherapy[J].Cell Chromosome,2004,3(1):2.
  • 4GOLDBERG A D,ALLIS C D,BERNSTEIN E.Epigenetics:a landscape takes shape[J].Cell,2007,128(4):635-638.
  • 5MINUCCI S,PELICCI P G.Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer[J].Nat Rev Cancer,2006,6(1):38-51.
  • 6GREGORETTI I V,LEE Y M,GOODSON H V.Molecular evolution of the histone deacetylase family:functional implications of phylogenetic analysis[J].J Mol Biol,2004,338(1):17-31.
  • 7BLANDER G,GUARENTE L.The Sir2 family of protein deacetylases[J].Annu Rev Biochem,2004,73(5):417-435.
  • 8PFLUM M K,TONG J K,LANE W S,et al.Histone deacetylase 1 phosphorylation promotes enzymatic activity and complex formation[J].J Biol Chem,2001,276(50):47733-47741.
  • 9BOTTOMLEY M J,LO SURDO P,DI GIOVINE P,et al.Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural Zinc-binding domain[J].J Biol Chem,2008,283(39):26694-26704.
  • 10TONG J J,LIU Jian-hong,BERTOS N R,et al.Identifi-cation of HDAC10,a novel class II human histone deacetylase containing a leucine-rich domain[J].Nuc Aci Res,2002,30(5):1114-1123.

引证文献5

二级引证文献19

医学研究生学报
2001年 第3期

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