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TLR4在内毒素导致组织损伤过程中的信号转导作用 被引量：2

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摘要 TLR4是内毒素激活信号转导的受体。LPS信号转导依赖于TLR4与LPS的直接作用。TLR4基因突变易感染革兰氏阴性细菌。对TLR4的研究有望给内毒素休克的治疗带来新的突破。并从阻断内毒素致病途径设想内毒素相关性疾病的治疗。
作者 李波静
机构地区 上海市第一人民医院消化内科
出处 《国外医学（生理病理科学与临床分册）》 2002年第6期630-633,共4页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
关键词 组织损伤 TLR4 信号转导 内毒素
分类号 R363 [医药卫生—病理学] R996.1 [医药卫生—毒理学]
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参考文献17

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同被引文献26

  • 1Wormhoudt LW, Commandeur JNM, Vermeulen NPE.Genetic polymorphisms of human N-acetyl transferase, cytochrome P450,glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity [ J ]. Cri Rev Toxicol, 1999,29: 59-124.
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  • 8Chan K, Han XD, Kan YW. An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen [ J ].PNAS, 2001, 98( 8 ): 4611-4616.
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引证文献2

国外医学（生理病理科学与临床分册）
2002年 第6期

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