摘要
目的 探讨偏头痛患者发作间期颅内血管血流动力学与血浆内皮素 (ET)和一氧化氮 (NO)含量及甲襞微循环改变的关系。方法 对 5 0例偏头痛患者采用经颅多普勒 (TCD)检测颅内血管血流动力学与甲襞微循环仪检测患者甲襞微循环指标 ,同时测定血浆ET、NO含量 ,并与 4 0名健康体检者 (对照组 )作对照。结果 偏头痛组TCD示颅内动脉血流速度增快 ,明显高于对照组 (P <0 .0 5 )。甲襞微循环示微血管狭窄 ,张力增加 ,加权积分值明显高于对照组 (P <0 .0 5～ 0 .0 0 1)。血浆ET明显高于对照组 ,血浆NO含量明显低于对照组 (均P <0 .0 1) ,与血流速度及血管收缩支数有关。结论 偏头痛患者发作间期颅内血管血流动力学异常与甲襞微循环异常有密切关系。其病理生理过程与缩血管因子ET及扩血管因子NO有密切相关 ,且与病情的严重程度有关。以上检测可作为判断偏头痛程度的参考指标 。
Objective To explore the relationship between intercranial hemodynamics and nitric oxide(NO),endothelin(ET),nailfold microcirculation in patients with migraine.Methods 50 patients with migraine and 40 normal controls underwent the measurement of intracranial hemodynamics,naifold microcirculation and the level of plasma ET,NO.The results of the two groups were compared and analyzed.Results The blood flow velocity of intracranial arteries was significantly higher in the patients than that in the normal controls( P <0.05).Capillary stenosis in nailfold microcirculation of the patients was more obvious than that of the normal controls( P <0.05～0.001) and the tension rose.The level of plasma ET was significantly higher,and the level of plasma NO were significantly lower in the patients than those in the controls( P <0.01).The levels of plasma ET and NO were related with the blood flow velocity and the vasoconstrictor number.Conclusion The abnormality of intracranial hemodynamics was significantly associated with the abnormality of naifold microcirculation.The pathophysiology was significantly associated with ET and NO in patients.Thereby nailfold microcirculation and the levels of ET and NO might be regarded as judging markers of migraine,which could help monitor the severity of migraine and guide the therapy.
出处
《临床神经病学杂志》
CAS
2002年第5期283-286,共4页
Journal of Clinical Neurology
关键词
偏头痛
经颅多谱勒
甲襞微循环
内皮素
一氧化氮
Migraine Transcranial Doppler Nailfold microcirculation Endothelin Nitric oxide
