摘要
[目的]判断肾小管炎出现在肾小球性疾病(非小管间质性)中的诊断价值和实际意义。[方法]712例肾穿刺活检组织行光镜、免疫荧光镜检查,并对肾小管炎等病理特征进行半定量计数。[结果]①在肾小球性疾病(非小管间质性)中,常出现肾小管炎改变。②肾小管炎的发生有其病变特异性,尤以血管病变相关性肾病、新月体性肾炎、糖尿病肾病等较为多见。③在急性、活动性病变中,肾小管炎的发生较严重,且多发生在尚未出现明显萎缩的小管中。慢性、非活动性病变中,受累小管多发生明显萎缩,且与肾间质炎性浸润及纤维化关系密切。④肾小管炎的浸润细胞多为淋巴及单个核细胞。[结论]在一些肾小球性疾病(非小管间质性冲可出现肾小管炎的病理改变,其发生与特定病理类型、肾小管间质炎症及纤维组织增生关系密切。肾小管炎的发生有可能参与并加重肾脏损害,在病理诊断中需注意观察。
[Objective] To observe the existence and extent of tubulitis in renal biopsy sample of 712 cases with non-tubulointerstitial glomerulonephritis, and evaluate to analyze the diagnostic value of tubulitis in non-tubulointerstitial glomerulonephritis. [Methods] The renal biopsies were examined by light microscopy, immunoflurecence and immuno-histochemistry techniques. [ Results ]① Tubulitis could be also observed in some non-tubulointerstitial glomerulonephritis, such as crescentic glomerulonephritis (GN), vascular lesion associated GN, diabetic nephropathy,etc.②Acute or active renal lesions were often associated with severe tubulitis, which might be found in non-atrophic and degeneration tubules. In chronic or non-active lesions, tubulitis could often be observed in the tubules with atrophy, broken of tubular basement membrane and degeneration, and was related to the surrounding interstitial inflammation and fibrosis. ③Most of infiltrating cells were lymphocytes and mononuclear cells. [ Conclusion ] Tubulitis may also be the pathologic epiphenomenon in non-tubulointerstial glomerulonephritis, which may be involved in the pathogenesis of tubulointerstitium injury of primary and/or secondary glomerulonephritis.
出处
《中山医科大学学报》
CSCD
北大核心
2003年第1期63-67,共5页
Academic Journal of Sun Yat-sen University of Medical Sciences
基金
广东省科委重点攻关基金(1995-9)
关键词
肾小管炎
诊断
病理学
免疫荧光镜
glomerulonephritis/pathology
nephritis, interstitial/pathology
