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肿瘤坏死因子β*2等位基因与狼疮性肾炎的相关性分析 被引量：4

Analysis of association between TNFa2allele and lupus neph ritis
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摘要 目的:进一步探讨肿瘤坏死因子β(TNFβ)基因在系统性红斑狼疮(SLE)发病中的作用。方法:采用聚合酶链反应和限制性片段长度多态性(PCR-RFLP)基因分型方法,检测98例SLE患者TNFβ等位基因,分析了TNFβ等位基因与SLE患者某些临床指标的相关性。结果:携带TNFβ2等位基因的SLE患者的肾炎发生率显著高于未携带TNFβ2等位基因的SLE患者(P<0.05)。结论:TNFβ2等位基因可能与狼疮性肾炎的发病相关。 Objective:To study the role of tumor necrosis factor ( TNF)aallele in the pathogenesis of systemic lupus ery-thematosus(SLE).Meth ods:Genotyping with PCR-RFLP was used to detect TN Faallele in98patients wi th SLE.The association of TNFaallele and some clinical features were analyzed .Results:The results showed that the incidence of nephritis in SLE patients wi th TNFa2allele was sig nificantly higher than those without TNFa2allele (P<0.05).Conclusion:This study suggests that the TNFa2allele might be associated with the pathogenesis of lupus nephritis.
作者 张江林 刘稚然 谢红付 施为 李宁
机构地区 中南大学湘雅医院皮肤科 中南大学湘雅医院中心实验室
出处 《临床皮肤科杂志》 CAS CSCD 北大核心 2003年第2期65-66,共2页 Journal of Clinical Dermatology
关键词 肿瘤坏死因子Β 等位基因 系统性红斑狼疮 狼疮性肾炎 tumor nec rosis factora allele lupus erythematosus,systemic
分类号 R593.242 [医药卫生—内科学]
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二级参考文献22

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共引文献10

同被引文献27

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临床皮肤科杂志
2003年 第2期

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