期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

细胞因子与糖尿病心肌病变 被引量：3

Cytokine and Diabetic Cardiomyopathy
暂未订购
导出
摘要 糖尿病心肌病是一种特异的心肌疾病,其发病机制尚未完全明了。细胞因子可以从影响心肌细胞舒缩性和心肌重构等方面参与其发病。本文就细胞因子各家族中与糖尿病心肌病发病关系密切的肿瘤坏死因子α、胰岛素样生长因子-1、转化生长因子β1等因子的研究进展作一综述。 Diabetic cardiomyopathy is a type of specific cardiomyopathy. Its exact mechanism is still undefined. Cytokines can affect myocardial contractility and myocardial remodelling in diabetic cardiomyopathy. In this review, the relationship between tumor neerosis factar-α（TNF-α）, insuline-like growth factor-1 （TGF-1）, transforming growth factar-β1 （TGF-β1） of the cytokine family and diabetic cardiomyopathy is summarized.
作者 温晨东 李兴
机构地区 山西医科大学第二医院内分泌科
出处 《医学综述》 2006年第1期34-36,共3页 Medical Recapitulate
关键词 肿瘤坏死因子Β 胰岛素样生长因子-1 转化生长因子Β1 糖尿病心肌病 Tumor necrosis factor-α Insuline-like growth factor-1 Trasforming growth factor-β1 Diabetic cardiomyopathy
分类号 R587.2 [医药卫生—内分泌]
  • 相关文献

参考文献19

  • 1Grunenfelder J, Nminiati D, Murata S, et al. Up regulmlon of Bcl-2 through hyperbaric pressure transfection of TGFβ1 ameliorates ischemiareperfusion injury in rat cardiac ano-Grafts[J]. J Heart Lung Transplant,2004,21(2) :244-250.
  • 2Song W, Lu X, Feng Q. Tumour necrosi factor alpha induces apoptosis via inducible nitric oxide synthese in neonatal mouse cardiomyocytes[J]. Cardiovas Res, 2004,45 (3) : 595-602.
  • 3Sivasubramanian N, Coker ML, Kurrelmeyer KM, et al. Left ventricular remodeling in transgenic mice with cardiac restricted overexpression of tumor necrosis factor [J]. Circulation, 2001,104 (7) : 826-831.
  • 4Grigsby RJ, Ddorowsky RT. Inhibition of ceramide production reverses TNF-induced insulin resistance [J]. Biochem Bioph Res Co, 2001,287(10) : 1121-1124.
  • 5Finck BN,Han X, Courtois M, et al. A critical role for PPAR alphamediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy:modulation by dietary fat content [J]. PNAS, 2003, 100 ( 3 ) : 1226-1231.
  • 6Hattofi Y, Matsuda N, Kimura J, et al, Diminished function and expression of the cardiac Na^+-Ca^2+ exchanger in diabetic rats : implication in Ca2^+ overload[J]. J Phvsiol, 2004,527( 1 ) : 85-94.
  • 7Liu T,I, Lai HC,Wu W, et al.Developing a strategy to define the effects of irmulin-like growth factor 1 on gene expression profile in eardiomyocytes[J]. Circ Res .2001.88(12):1231-1238.
  • 8Li Q , Li B, Wang X, et al. OverexpresAion of irmulin-like gwowth factor 1 in mice protects from myocyte death after infarction,attenuating ventricular dilation, wall stress, and cardiac hypertrophy [J]. J Clin Invest,1997,100(8) : 1991-1999.
  • 9Chao W, Matsui T, Novikov MS, et al. Strategic advantages of insulinlike growth factor-1 expression for cardioprotection[J] .J Gene Med,2003,5(4) :277-286.
  • 10夏艳秋,徐永平,李淑英,单保党,甄宇红.胰岛素样生长因子-Ⅰ在心血管疾病发病机制中的作用[J].国外医学（生理病理科学与临床分册）,2004,24(3):229-232. 被引量：8

二级参考文献20

  • 1Okura Y, Brink M, Zahid AA, et al. Decreased expression of insulin-like growth factor- I and apoptosis of vascular smooth muscle cells in human atherosclerotic plaque[J]. J Mol Cell Card, 2001,33 : 1777-1789.
  • 2Ruiz-Torres A. The role of insulin-like growth factor I and insulin in ageing and atherosclerosis[ J]. Novartis Found Symp, 2002, 242 : 143-153.
  • 3Van den Beld AW, Bots ML, Janssen JA, et o2. Endogenous hormones and carotid atherosclerosis in elderly men [ J ]. Am J Epidemiol, 2003,157( 1 ) :25-31.
  • 4Anwar A, Zahid AA, Scheidegger KJ, et al. Tumor necrosis factoralpha regulates insulin-like growth factor- I and insulin-like growth factor binding protein-3 expression in vascular smooth muscle [ J ]. Circulation, 2002,105 : 1220-1225.
  • 5Twickler TB, Bruckert E, Cramer M J, et al. The growth hormone/ insulin-like growth factor axis. What is its role in the atherosclerotic process? [J]. Presse Med, 2003, 32(26):1238-1243.
  • 6Juul A, Scheike T, Davidsen M, et al. Low serum insulin-like growth factor I is associated with increased risk of ischemic heart disease: a population-based case-control study [ J ]. Circulation,2002,106( 8 ) :939-944.
  • 7Su EJ, Cioffi CL, Stefansson S, et al. Gene therapy vector-mediated expression of insulin-like growth factors protects cardiomyocytes from apoptosis and enhances neovascularization[ J]. Am J Physiol Heart Circ Physiol, 2003,284(4) :H1429-4dO.
  • 8Von Lewinski D, Voss K, Hulsmann S, et al. Insulin-like growth factor- I exerts Ca^2+ -dependent positive inotropic effeots in failing human myocardium[J]. Circ Res, 2003,92(2) :169-176.
  • 9Otani H, Yamamura T, Nakao Y, et al. Insulin-like growth factor-I improves recovery of cardiac performance during reperfusion in isolated rat heart by a wortmannin-sensitive mechanism [ J ]. Journal of Cardiovascular Pharmacology. 2000.35:275-281.
  • 10Yamamura T, Otani H, Nakao Y, et al. IGF-I differentially regulates Bcl-xL and Bax and confers myocardial protection in the rat heart[ J ]. Am J Physiol Heart Circ Physiol, 2001,280 ( 3 ) : H1191 -200.

共引文献7

同被引文献31

引证文献3

二级引证文献2

医学综述
2006年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部