摘要
目的 :评价血清SIL - 2R ,IL - 6 ,IL - 10和CL -Ⅳ对早期诊断肾移植排斥反应的价值。方法 :检测了 34名肾移植病人及 2 0名正常对照者血清SIL - 2R ,IL - 6 ,IL - 10 ,CL -Ⅳ的水平 ,通过分析特征工作曲线(ROC)评价其对早期诊断肾移植排斥反应的价值。结果 :在肾移植排斥组中 ,SIL - 2R ,IL - 6及IL - 10均显著高于肾功能稳定组及正常对照组 ,而CL -Ⅳ在排斥组及肾功能稳定组间无明显差异 ,但高于正常对照组。通过ROC曲线下面积分析 ,发现IL - 6最为敏感 ,SIL - 2R次之 ,IL - 10与CL -Ⅳ效果较差。结论 :SIL -2R和IL - 6是监测肾移植早期排斥反应的良好指标。
Objective:To assess the Value of SIL-2R,IL-10 and CL-Ⅳ in plasma were meassured in 34 renal allograftei patients and 20 normal persons. ROC was used to assess these indexes. Results:The levels of SIL-2R, IL-6, IL-10 in acute rejection growp were significant higher than those in renal allograft without rejection and normal groups. The CL-Ⅳ was no significant difference betwecn acute rejection group and without rejection group,but higher than the normal group. The sensitivity of IL-6 and IL-2 were higher than IL-10 and CL-Ⅳ by ROE analysis.Conclusions:SIL-2R and IL-6 are good indexes in early diagnosis renal graft rejection.
出处
《中国现代医学杂志》
CAS
CSCD
2003年第1期53-55,共3页
China Journal of Modern Medicine
