摘要
目的研究发现正常人血中IL-6水平很低,然而重症病人感染时其水平急剧升高.方法为了给该类病人预后的正确评估提供科学依据,本研究采用ROC曲线对此类病人IL-6的预后价值进行评价.结果40例重症合并感染的病人血清IL-6水平均数为(152.02±55.77)pg/mL,重症非合并感染病人的血清IL-6水平均数为(130.98±50.72)pg/mL,二者均升高,但该两组的血清IL-6水平比较无显著性差异(P>0.05),它们与正常对照组IL-6(85.79±30.96)pg/mL比较均有显著性差异(P<0.01).IL-6水平的ROC曲线下面积值为0.885;APACHEⅡ评分ROC曲线下的面积值为0.766.结论血清IL-6水平和A-PACHEⅡ评分相比,对于重症合并感染病人预后的预测,血清IL-6水平是较好的预测因子.
Objective It is found out that serum IL -6 is very low in normal persons, however, it increases dramatically to a high lever in severe patients with infection. Methods To offer a scientific evident for prognosis of that sort of patients, we determined to appraise its prognosis value in those patients by using of the POC curve. Results The serum IL- 6 average of 40 severe patients with infection was （152. 02 ± 55.77 ） pg/ mL The serum IL - 6 average of 30 severe patients without infection was （ 130. 98 ± 50. 72 ） pg/mL. Lever of IL -6 of the two groups both increase, but they had not statistic difference （ P 〉0. 05） . However, the normal contrapose group＇ s average was （85.79 ± 30. 96 ） pg/mL. Comparing with either of the two groups, they both had statistic difference （ P 〈 0. 01 ）. The area under the ROC curve of IL - 6 was 0. 885, and the area under the ROC curve of APACHE Ⅱ Score was 0. 766. So, as far as to evaluate sever patients prognosis, the serum IL - 6 is more susceptivity than APACHE Ⅱ Score. In short, the usage of the serum IL - 6 is a useful way to evaluate sever patients＇ prognosis, at least, we should recommend it as an affiliated method.
出处
《昆明医学院学报》
2006年第4期107-110,共4页
Journal of Kunming Medical College
