摘要
在不同 p H值下 ,测定 11种苯酚类化合物对大型蚤 (Daphnia Magna) 2 4 h的半数活动抑制浓度 IC50 .应用 3种理化参数 log P,TSA和 p Ka,对毒性数据进行定量构效相关 (QSAR)研究 .在此基础上 ,初步探讨苯酚类化合物的毒性机制 .
The toxicity of 11 kinds of phenol chemicals to Daphnia Magna at pH 6.0, 7.8 and 9.0 are reflected by measuring the concentration for inhibiting the activities of half of them during 24 hours, or IC 50 for short. The study of quantitative structure-activity relationships, or QSAR for short, is made on toxicity data by applying 3 kinds of physicochemical parameters log P , TSA and pKa. On this basis, an initial inquiry is made into the mechanism of toxicity of phenol chemicals.
出处
《华侨大学学报（自然科学版）》
CAS
2003年第1期44-47,共4页
Journal of Huaqiao University(Natural Science)
基金
华侨大学科研基金资助项目 (0 2 HZR0 1)
