摘要
目的 研究抗癌药物马蔺子素与 β 环糊精的主 客体包络行为。 方法 在悬汞电极上用循环伏安法考察β 环糊精不存在和存在时马蔺子素还原波的变化。结果 在 0 0 4mol·L- 1 KH2 PO4 Na2 HPO4(pH 6 8)近生理介质中 ,β 环糊精的引入使马蔺子素的还原波峰电流降低 ,峰电位正移。结论 电活性客体分子马蔺子素与主体分子 β 环糊精生成 1∶1的包络物。用“电流法”测得其形成常数Kf 值为 1 92× 10 3 L·mol- 1 。包络物的生成增强了马蔺子素的稳定性。
AIM To study the host-vip inclusion behavior of anticancer drug irisquinone with β-cyclodextrin. METHODS The variance of the reduction ware of irisquinone in the absence and presence of β-cyclodextrin was examined by cyclic voltammetry at the hanging mercury drop electrode. RESULTS In 0.04 mol·L -1 KH 2PO 4-Na 2HPO 4 (pH 6.8) supporting electrolyte which was close to physiological condition, the introduction of β-cyclodextrin resulted in both decrease of reduction current and the positive shift of peak potential of reduction ware of irisquinone. CONCLUSION The electroactive vip molecule irisquinone was complexed with host molecule β-cyclodextrin to the formation of 1∶1 inclusion complex. The inclusion constant K f was 1.92×10 3 L·mol -1 by the electric current method. The formation of the inclusion complex enhanced the stability of irisquinone.
出处
《药学学报》
CAS
CSCD
北大核心
2002年第12期963-966,共4页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目 ( 2 9875 0 17)
