1Pike CJ,Burdick D,Walemcewicz AJ,et al.Neurodegenaratic induced by β-amyloid peptides in vitro:the role of peptide assembly state[J].J Neutosci,1993,13:1676.
2Roberds SL,Anderson J,Basi G,et al. BACE knockout mice are healthy dispite lacking the primary beta-secretase activity in brain:implications for Alzheimer's disease therapeutics[J].Hum Mol Genet,2001,10(12):1317～1324.
3Bart D,Gerhard K.A firm base for drug development[J].Nature,1999,402:471～472.
4Esler WP,Kimberly WT,Ostaszewski BL,et al.Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1[J].Nat Cell Biol,2000,2(7):428～434.
5Pennisi E.Enzymes point way to potential Alzheimer's therapies[J].Science,1999,286:650～651.
6Michelle L,Steinhilb R.The protease inhibitor,MG132,Blocks maturation of the amyloid precursor protein swedish mutant preventing cleavage bu-Secretase[J].The Journal of Biological Chemistry,2001,276(6):4476～4477.
7Monji A,Yoshida I,Tashiro K,et al.Inhibition of A beta fibril formation and A beta-induced cytotoxicity by senile plaque-associated proteins[J].Neurosci Lett,2000,7:278(1～2):81～84.
8McGeer PL,Kawamata T,Walker DG.Disteibution of clusterin in Alzheimer's brain tissue[J].Brain Res,1992,579:337.
9Gouras GK,Xu H,Gross RS,et al.Testosterone reduce neuronal secretion of Alzheimer's beta-amloid peptide[J].Proc Natl Acad Sci U S A,2000,97(3):1202～1205.
10Games D,Bard F,Grajeda H,et al.Prevention and reduction of AD-type pathology in PDAPP mice immuneized with A beta 1～42[J].Ann N Y Acad Sci,2000,920:274～284.
4[4]Tangui m,Grian PL,Alain P. Amnesia induced in mice by centrally administered β-amyloid peptides involves cholinergic dysfunction[J]. Brain Res,1996,706(2):181-193.
5[5]Nitta A, Itoh A, Hasegawa T, et al. β-amyloid protein induced Alzheimer's disease animal model[J]. Neurosci Lett, 1994,170(1):63-66.
6[6]Giovannelli L, Casamenti F, Scali C, et al. Differential effects of amyloid peptidesβ-(1-40) and β-(25-35) injections into the rat nucleus basalis[J].Neuroscience,1995,66(4):781-792.
