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老年性痴呆中β淀粉样肽的研究进展 被引量：10

Development of beta-amyloid peptide in senile dementia
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摘要 老年性痴呆(阿尔茨海默病,Alzheimerdisease,AD)患者脑内老年斑的主要成分为β淀粉样肽(β-AmyloidPeptide,Aβ),其生理功能以及合成和代谢的过程中相关基因和酶的作用近年来的研究有了许多新的进展,揭示了Aβ与AD病的内在联系及其在治疗方面的一些新的方法,抑制毒性Aβ的合成聚集是治疗AD的一个新的突破。
作者 代蓉 殷义涛 高秀云
机构地区 昆明医学院第一附属医院康复理疗科
出处 《中国临床康复》 CSCD 2004年第19期3858-3859,共2页 Chinese Journal of Clinical Rehabilitation
关键词 老年性痴呆 Β淀粉样肽 阿尔茨海默病 治疗 老年斑
分类号 R749.16 [医药卫生—神经病学与精神病学]
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参考文献21

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  • 3刘勉,叶蕴华.β-淀粉样肽的结构、合成与性质及其与老年痴呆症的关系[J].化学通报,2002,65(7):458-462. 被引量：3
  • 4[4]Hook VY, Reisine TD. Cysteine proteases are the major beta-secretase in the regulated secretory pathway that provides most of the beta-amyloid in Alzheimer's disease: role of BACE 1 in the constitutive secretory pathway. J Neurosci Res2003; 74(3): 393 -405
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二级参考文献71

  • 1Selkoe DJ.Alzheimer's disease: genes, proteins, and therapy.Physiol Rev 2001;81(2):741-66
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  • 8Luo Y, Bolon B, Kahn S, et al.Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation.Nat Neurosci 2001;4(3):231-2
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中国临床康复
2004年 第19期

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