摘要
本实验应用光镜、电镜对大鼠吸入100±15ppm硫化氢(H_2S)3h后15d内肺的形态变化作了动态观察。结果发现病变广泛累及支气管上皮、肺泡上皮、肺小血管及间质。肺水肿、灶性肺出血、退变上皮的脱落及中性白细胞渗出见于中毒后3h～3d,慢性炎症及纤维组织增生见于中毒后7～15d。肺泡上皮、吞噬细胞、血管内皮、纤维母细胞及炎细胞的超微结构变化明显。肺水肿初为间质性并渐波及肺泡腔。肺泡表面活性物质碎片见于中毒后3h～3d。实验结果表明H_2S对肺具有广泛的损伤作用。
The pathological changes of the lungs after a single exposure to an atmosphere containing 100±15 ppm of hydrogen sulfide(H2S)for 3 hours were observed with optical and electron microscopy in rats.It was found that bronchial epitheliem,alveolar epithelium,pulmonary vessels and pulmonary interstitium were extensively involved.Pulmonary edema,focal pulmonary hemorrhage,exfoliation of the damaged epithelium,and infiltration of neutrophils occurred mainly in the 3rd hour to the 3rd day after H2S intoxication.Chronic inflammatory response and proliferation of fibrous tissue occurred mainly from the 7th to the 15th day after intoxication.Ultrastruc-turally,there were marked changes of alveolar epithelium,phagocytes,vascular endothelium,fi-broblasts,and inflammatory cells.Initial pulmonary edema emerged in the pulmonary interstitium and gradually affected the alveoli.Fragments of alveolar surfactant could be seen in the 3rd hour to the 3rd day after intoxication.These findings indicate that H2S inhalation exerts extensive injurious effects on the lungs in the rats.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1992年第4期343-346,共4页
Journal of Third Military Medical University
关键词
硫化氢类
肺水肿
气体中毒
hydrogen sulfide/PO
pulmonary edema
hemorrhage
rats
