摘要
本实验观察了狗中度冲击伤、肢体破片伤及两者复合伤后24h内肺动脉平均压(PAP)、动脉血浆及肺组织中前列环素(6-keto-PGF_1α)与血栓素(TXB_2)的变化。结果表明,冲击伤、破片伤及复合伤后PAP、动脉血浆及肺组织中TXB_2均有升高,PAP以复合伤后升高最为明显。TXB_2在破片伤及复合伤后的变化幅度高于冲击伤后。6-keto-PGF_1α在冲击伤、破片伤后血浆及肺组织中均有升高,但在复合伤后血浆中有所下降,肺组织中则无明显变化。本文讨论了这些变化的意义。
The changes of mean pulmonary arterial pressure (PAP) and 6-keto-PGF1a and TXB2 in the plasma and lung tissues of 3 groups of dogs (7 in each group) with blast injury (group Ⅰ),high velocity shell fragment injury on one of the extremities (group Ⅱ),and combined injury of the both (group Ⅲ) were investigated.It was found that PAP and TXB2 in the plasma and lung tissues increased after all the 3 kinds of injuries.The changes of PAP was most marked in group Ⅰ while those of TXB2 was more marked in groups Ⅲ and Ⅲ than in group Ⅰ.6-kcto-PGF1a increased in the plasma and lung tissues after blast and shell fragment injury but decreased in the plasma and showed no changes in the lung tissues after combined injury.The significance of these changes of 6-keto-PGF1a and TXB2 in the 3 kinds of injuryies were discussed.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1992年第3期270-273,共4页
Journal of Third Military Medical University
关键词
爆炸伤
前列腺素X
血栓素
blast injuries
prostaglandins X
thromboxane
