摘要
应用核团刺激和损毁法,研究了下丘脑室旁核(PVH)在痛觉调制中的作用。电刺激PVH或PVH内注射谷氧酸钠均可使大鼠痛阈升高,且有量效关系。电解损毁PVH则使痛阈降低。摘除脑下垂体对PVH内注射谷氨酸钠所致的痛阈升高没有明显影响。表明PVH任痛觉调制中具有重要作用,而且这种作用主要是通过中枢实现的。
Methods including stimulation, cauterization, of nuclei and measurement of pain threshold were used to clarify the role of paraventricular nucleus of hypothalamus (PVH) in pain regulation. Results showed that electrical or L-glutamate sodium stimulation of PVH could elevate the pain threshold in the rat dose-dependently, electrical cauterization of PVH could reduce the pain threshold; and removal of the pituitary gland could not influence the effect of L-glutamate sodium on pain threshold. These results suggest that PVH may play an important role in pain regulation.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1992年第2期120-124,共5页
Academic Journal of Second Military Medical University
基金
国家自然科学基金
关键词
下丘脑室旁核
痛觉调制
痛阈
大鼠
paraventricular nucleus of hypothalamus
pain regulation
pain threshold
rats
