摘要
目的 测定剖腹产妇乳汁中甲硝唑的含量。方法 采用反相高效液相色谱法 ,固定相为 Hypersil C18柱 ,以甲醇 - 0 .0 1 mol·L-1磷酸二氢钠 (3 0∶ 70 )为流动相 ,内标物为水杨酸 ,检测波长为 2 77nm。结果 静脉滴注后 1 h和 5 h的乳汁中甲硝唑的含量分别为 6 .94g·L-1和 4.83 g·L-1。结论 本法操作简便 ,结果准确 。
Objective To determine metronidazole in milk of cesarean women. Method The HPLC method employed a Hypersil C 18 column with methanol-0.01 mol·L -1 NaH 2PO 4(30∶70) as the mobile phase, internal standard was salycylic acid, the wavelength of detection was 277 nm. Results The concentrations of 1 h and 5 h after intravenous drip were 6.94 g·L -1 and 4.83 g·L -1 respectively. Conclusion The method was simple, accurate and suitable for the clinical study.
出处
《西北药学杂志》
CAS
2002年第6期243-244,共2页
Northwest Pharmaceutical Journal
