摘要
目的 :探讨同时应用支气管动脉灌注化疗和外放射治疗两种治疗方法治疗中晚期肺癌的疗效。方法 :采用Seldinger技术 ,经支气管动脉灌注化疗药物 :顺铂 6 0mg m2 ,阿霉素 4 0mg m2 ,丝裂霉素 6mg m2 或 5 FU 75 0mg m2 。每 3～ 4周灌注 1次 ,3～ 4次为 1个疗程。放疗于灌注后 10～ 15d进行。放射源为60 Co ,所有病例均为对穿照射。剂量DT2Gy 次 ,5次 周 ,总量DT5 0～ 6 0Gy 2 5～ 30次 ,共5～ 6周。结果CR 8例 (2 2 2 % ) ,PR 2 3例 (6 3 6 % ) ,S 3例 (8 6 % ) ,P 2例 (5 6 5 % )。总有效率CR +PR为 (85 6 % ) ,2年生存率 2 7 8%。结论 :支气管动脉灌注加外放射治疗肺癌有协同作用 ,是目前治疗中晚期肺癌的一种安全。
objective To study the therapeutic effect of bronchial artery agents infusion and radiotherapy on advanced pulmonary carcinomas.Methods 36 cases were treated with bronchial artery infusion.Chemotherapy drugs were DDP 60 mg/m 2;ADM 40 mg/m 2;MMC 6 mg/m 2 or 5 FU 750 mg/m 2.The treatment was given every 3 or 4 weeks,and 3 or 4 infusions constituted a course of treatment.After 10 15 days,all cases were given radiotherapy of D T 2 Gy( 60 Co),5 fractions every week,total dose was 50 60 Gy for 25 30 fractions for 5 6 weeks.Results The effective rate was 85 6%(CR 8 and PR 23).2 year survival rate was 27 8%.Conclusions The bronchial artery agents infusion and external irradiation can enhence the effect of the advanced pulmonary carcinoma.
出处
《肿瘤防治杂志》
2002年第6期614-615,共2页
China Journal of Cancer Prevention and Treatment
