摘要
目的探讨多发性肌炎/皮肌炎(PM/DM)的临床及病理特点,以及这些特点与疗效及预后的关系。方法对83例PM/DM患者的临床资料进行总结、分析。结果PM/DM以肌无力、肌肉压痛、血清肌酶谱增高为主要临床表现,伴肌电图及病理学检查异常;经肾上腺皮质激素和免疫抑制剂等治疗后,总有效率86.7 %。结论PM/DM各型之间临床与病理表现的差异提示可能存在不同的发病机制。神经损害是全身系统损害的一部分。PM/DM的预后与分型、治疗时机有关,早期强有力的治疗可望改善预后。
Objective To study the clinical and pathological characteristics and treatment of polymyositis (PM) and dermatomyositis (DM). Methods Eighty-three DM/PM cases were reviewed and analyzed. Results The main clinical presentations of PM/DM included amyosthenia, muscular tenderness, elevation of serum enzymes, accompanied by abnormal electromyography and muscular pathology. A total efficacy rate of 86.7% was achieved after treatment with corticosteroid and immuno- depressants. Conclusions The different clinical and pathological presentations of various types of PM/DM suggest different pathogenesis between DM and PM. Nerve damage is a part of the systemic damages due to the disease, the prognosis of which is related to its classification and then timing of the treatment. Early effective treatment can improve the prognosis.
出处
《第一军医大学学报》
CSCD
北大核心
2002年第12期1138-1140,共3页
Journal of First Military Medical University
关键词
多发性肌炎
皮肌炎
结缔组织病
诊断
治疗
病理特点
预后
PM
DM
polymyositis
dermatomyositis
conjunctive tissue diseases/diagnosis, therapy
pathological analysis
