摘要
目的 研究苦豆子总碱对辐射损伤小鼠脂质过氧化作用的影响。方法 小鼠腹腔注射不同剂量的苦豆子总碱 ,60 Coγ射线全身均匀照射、吸收剂量 5 0Gy ,检测苦豆子总碱对肝组织中丙二醛 (MDA)含量、血清谷丙转氨酶 (GPT)、谷草转氨酶 (GOT)、超氧化物歧化酶 (SOD)以及全血中硒 谷胱苷肽过氧化物酶 (Se GSH PX)活力的影响。结果 辐射损伤后小鼠脱毛明显、体重减轻、尾部出现多个出血斑 ,MDA含量增高 ,SOD及GSH PX活力下降 ,GPT、GOT活力增加。苦豆子总碱可促进上述指标恢复。结论 苦豆子总碱对受照小鼠具有一定的保护作用 ,其机理可能与抗氧化作用有关。
Objective\ To study the effects of total base of Sophora alopecuroides on lipid peroxidation of irradiated mice. Methods\ The mice were treated orally with different doses of total base of Sophora alopecuroides,after exposed to whole\|body 60 Co γ\|rays at a dose of 5\^0 Gy.The content of MDA in the liver and activities of Se\|GSH\|PX,SOD,GPT,GOT were measured. Results\ After irradiation,the general status of the mice were changed such as hair deprivation,body weight reduction,blood spots appeared on the tail.Activities of Se\|GSH\|PX,SOD decreased remarkablely,whereas those of GPT and GOT increased.MDA contents increased obviously.Oral administration of total base of Sophora alopecuroides could accelerate restoration of these indexs. Conclusion\ Total base of Sophora alopecuroides has certain protective effects on irradiated mice,the mechanism of which may be related with antioxidation.\;
出处
《中华放射医学与防护杂志》
CAS
CSCD
北大核心
2002年第5期319-321,共3页
Chinese Journal of Radiological Medicine and Protection
