摘要
文报告11例地方性氟中毒患者、10例患者子女及19例正常健康人对照组外周血淋巴细胞SCE频率的观察结果:(1)地方性氟中毒患者SCE频率明显高于正常对照组,差异非常显著(P<0.01);(2)患者发病后出生的子女的SCE频率明显高于正常对照组,差异也非常显著(P<0.01)。
In our study me frequencies of SCE, in me penpnerai lymphocytes of 11 patients witn endemic fluorosis and their 10 children were observed. The frequencies of SCE in 19 normal control groups were also analyzed so as to compare between those of the patients and their children. The results obtained from the total samples are as follows:(l) The SCE frequency of patients with endemic fluorosis is significantly higher than that of the normal control groups, P<0.01. (2)The SCE frequency of their children is also significantly higher than normal control groups, P< 0.01.
The results indicated that the patients with endemic fluorosis and their children have significatly higher SCE frequencies, and these data may be considered a new idea to study genetic factors acting on the mechanism of endemic fluorosis.
出处
《地方病通报》
1992年第2期115-117,共3页
Endemic Diseases Bulletin
关键词
氟中毒
淋巴细胞
SCE
Endemic fluorosis
Cases
Peripheral lymphocytes
Sister chromatid exchange (SCE)
