摘要
本文研究了氟对大鼠免疫器官的影响及“抗氟灵”对氟的拮抗作用。２４只大鼠被随机分成３组，Ａ组为阴性对照组，Ｂ组为染氟组，Ｃ组为氟加“抗氟灵”组。观察与检测了所有动物的胸腺及脾脏的蛋白质含量，脏器重量，脏器系数及形态学变化。结果显示：Ｂ组动物胸腺与脾脏的蛋白含量，脏器重量，脏器系数均明显下降，胸腺皮质明显变薄，淋巴细胞稀疏；Ｃ组动物的这些指标变化不明显。提示氟对大鼠免疫器官具有一定的损害作用，而“抗氟灵”对此有部分拮抗作用。
The effects of fluoride on immune organ in rats and the antagonistic effects of 'Kangfuling' were studied 24 rats were randomly divided into three groups. Group A served as negative control,group B was treated with NaF orally and group C was treated with NaF solution containing'Kangfuling' orally, The weights, organ indexes, levels of protein and morphology of thymus and spleen were examined in all rats. The results showed that protein contents and organ indexes of thymus and spleen were significantly reduced.thymus cortex became thin,and lymphocytes were sparse in group B. However, no apparent difference was found in group C compared with group A after exposure to fluoride for 2 months, It suggested that fluoride could damage thymus and spleen in rats and the antagonistic effects of 'Kangfuling' has been observed.
出处
《工业卫生与职业病》
CAS
CSCD
1996年第3期152-154,共3页
Industrial Health and Occupational Diseases
基金
中国有色金属总公司"八.五"项目
冶金工业部资助基金
关键词
氟化钠
免疫器官
抗氟灵
拮抗作用
Sodium fluoride
Immune organ
Fluoride
Antagonism
