摘要
【目的】探讨补肾益心片对高血压大鼠血压及血液流变学的影响。【方法】采用双肾一夹型(2K1C)高血压模型大鼠,随机分为高、低剂量中药组各13只,生理盐水(NS)组、尼群地平组各12只,10只假手术组作正常组。分别给高、低剂量中药组灌胃补肾益心片水溶液25g·kg-1·d-1,6.25g·kg-1·d-1,尼群地平组灌胃尼群地平10mg·kg-1·d-1,NS组灌胃NS2mL·d-1,假手术组正常喂食,各组测定鼠尾动脉血压。治疗4周后取血,测定全血粘度、红细胞聚集指数和变形性指数。【结果】高血压造模大鼠血压升高,高、中、低切全血粘度均较正常大鼠明显升高,红细胞聚集指数明显增加,红细胞变形指数明显降低。与生理盐水组比,治疗后补肾益心片组和尼群地平组血压均显著降低,全血粘度下降,红细胞变形指数增加(P<0.05),中药高剂量组红细胞聚集指数显著下降(P<0.05)。【结论】补肾益心片可降低2K1C模型大鼠的血压,降低全血粘度,抑制红细胞聚集,改善红细胞变形性。
[Objective] To evaluate the effect of Bushen Yixin Tablet (BYT) on blood pressure (BP) and hemorrheology in rats with hypertension. [Methods] Rat models of hypertension were established by constricting either of the bilateral renal arteries with one clip. Sixty rats were randomly allocated to high - dose BYT group (Group A), low - dose BYT group (Group B), nitrendipine (Group C) and normal saline group (Group D) . Ten rats served as mimic group (Group E) . BP of tail artery was examined in various groups and after a 4 - week treatment, whole blood viscosity and indexes of erythrocyte aggregation (EA) and erythrocyte deformation (ED) were detected. [Results] BP was increased, high- , middle - and low - shear whole blood viscosity and EA index were elevated and ED index was decreased in model rats as compared with those of the normal. After treatment, BP and whole blood viscosity were reduced and ED index was increased in Group A, Group B and Group C, and EA index in Group A was lowered as compared with those in Group D (P < 0.05). [Conclusion] BYT can decrease BP, reduce whole blood viscosity, inhibit EA and improve ED.
出处
《广州中医药大学学报》
CAS
2002年第4期292-294,共3页
Journal of Guangzhou University of Traditional Chinese Medicine
关键词
补肾益心片
高血压
大鼠
血液流变学
HYPERTENSION/TCD therapy
BUSHEN YIXIN TABLET/phaimacology
HEMORRHEOLOGY
DISEASE MODELS, ANIMAL
RATS
