摘要
抽动障碍(TD)是一种常见于儿童和青少年的神经精神性疾病,其发病与神经炎症反应及免疫调节异常密切相关,主要表现为不自主的运动性和发声性抽动。近年来,TNF-α炎症信号通路在TD的病理机制中起重要作用,参与调节神经炎症反应、影响神经元兴奋性及突触传递过程。中医药通过整体调节和多靶点干预,针对TNF-α信号通路中的多个关键环节进行调控,从而减轻神经炎症、抑制过度免疫应答并改善神经功能。本文系统综述中医药通过调控TNF-α炎症信号通路治疗TD的研究进展,重点探讨其在抑制TNF-α介导的神经炎症、调节胶质细胞活化及神经免疫微环境等方面的作用机制,揭示中医药在调节神经递质平衡、保护神经元及改善行为症状等方面的综合调控优势,为阐释中医药治疗TD的现代药理机制提供理论依据,并为靶向TNF-α信号通路的中医药创新研究提供思路与方向。
Tic disorder(TD)is a common neurological and psychiatric disorder in children and adolescents,its onset is closely related to neuroinflammatory response and immune regulation abnormalities,mainly manifested as involuntary motor and vocal tics.In recent years,TNF-αinflammatory signaling pathway has played an important role in pathological mechanism of TD,participating in regulating neuroinflammatory responses,affecting neuronal excitability,and synaptic transmission processes.Traditional Chinese medicine and pharmacy regulates multiple key links in TNF-αsignaling pathway through holistic regulation and multi-target intervention,thereby reducing neuroinflammation,inhibiting excessive immune response,and improving neurological function.This article systematically reviews research progress on traditional Chinese medicine and pharmacy in the treatment of TD by regulating TNF-αinflammatory signaling pathway,focuses on exploring its action mechanism in inhibiting TNF-αmediated neuroinflammation,regulating glial cell activation,and neuroimmune microenvironment,reveals comprehensive regulatory advantages of traditional Chinese medicine and pharmacy in regulating neurotransmitter balance,protecting neurons,and improving behavioral symptoms,in order to provide theoretical basis for explaining modern pharmacological mechanism of traditional Chinese medicine and pharmacy in the treatment of TD,and provide ideas and directions for innovative research in traditional Chinese medicine and pharmacy targeting TNF-αsignaling pathway.
作者
孙一凡
周正
郭智丹
梁绿圆
孔亚敏
马丙祥
SUN Yifan;ZHOU Zheng;GUO Zhidan;LIANG Lvyuan;KONG Yamin;MA Bingxiang(Pediatric Medical College,Henan University of Chinese Medicine,Henan Province,Zhengzhou 450000,China;the Third Department of Paediatrics,Pediatric Hospital,the First Affiliated Hospital of Henan University of Chinese Medicine,Henan Province,Zhengzhou 450000,China;Department of Paediatrics,Henan Integrative Medicine Hospital,Henan Province,Zhengzhou 450000,China)
出处
《中国医药导报》
2026年第7期164-168,173,共6页
China Medical Herald
基金
国家自然科学基金资助项目(81973904)
河南省中医药科学研究专项课题(2023ZXZX1099)。
关键词
抽动障碍
TNF-α信号通路
炎症
中药
复方
作用机制
Tic disorder
TNF-αsignaling pathway
Inflammation
Chinese materia medica
Compound prescription
Action mechanism
