摘要
目的探讨超声测定肝脏脂肪含量(LFC)联合血清细胞角蛋白18-M30片段(CK18-M30)、细胞角蛋白18-M65片段(CK18-M65)、成纤维细胞生长因子受体1(FGFR1)在诊断非酒精性脂肪性肝病(NAFLD)中的应用价值。方法选取2024年1月至2025年3月景宁畲族自治县人民医院收治的NAFLD患者92例作为研究组,根据病情分为轻度组(n=35)、中度组(n=31)、重度组(n=26),另外选取同期健康体检者92例作为对照组。两组均行超声检查测定LFC水平及血清CK18-M30、CK18-M65、FGFR1水平并进行比较,通过Spearman相关性分析其与NAFLD患者病情严重程度的相关性,并绘制受试者工作特征(ROC)曲线分析LFC联合血清CK18-M30、CK18-M65、FGFR1诊断NAFLD的诊断价值,获取曲线下面积(AUC)。结果研究组LFC及血清CK18-M30、CK18-M65、FGFR1水平高于对照组,重度组高于中度组和轻度组(P<0.05),中度组高于轻度组(P<0.05)。Spearman相关性分析结果显示,LFC及血清CK18-M30、CK18-M65、FGFR1水平与NAFLD患者病情严重程度呈正相关(r=0.651、0.577、0.569、0.613,P<0.05)。ROC曲线分析结果显示,LFC联合血清CK18-M30、CK18-M65、FGFR1诊断NAFLD的AUC值为0.919,高于各指标单独检测(0.811、0.803、0.820、0.837,P<0.05)。结论NAFLD患者LFC及血清CK18-M30、CK18-M65、FGFR1水平均较高,四者与患者病情密切相关,且四者联合检测对诊断NAFLD更具优势。
Objective To investigate the diagnostic value of ultrasound measured liver fat content(LFC)combined with serum cytokeratin 18-M30 fragment(CK18-M30),cytokeratin 18-M65 fragment(CK18-M65)and fibroblast growth factor receptor 1(FGFR1)in non-alcoholic fatty liver disease(NAFLD).Methods A total of 92 patients with NAFLD admitted to Jingning People's Hospital from January 2024 to March 2025 were enrolled as the study group and divided into mild group(n=35),moderate group(n=31)and severe group(n=26)according to disease severity.Another 92 healthy subjects undergoing physical examination during the same period were selected as the control group.Ultrasound-measured LFC and serum levels of CK18-M30,CK18-M65 and FGFR1 were detected and compared between the two groups.Spearman correlation analysis was used to analyze their correlation with the severity of NAFLD.Receiver operating characteristic(ROC)curves were plotted to analyze the diagnostic value of ultrasound measured LFC combined with serum CK18-M30,CK18-M65 and FGFR1 for NAFLD,and the area under the curve(AUC)was calculated.Results The levels of ultrasound-measured LFC and serum CK18-M30,CK18-M65,FGFR1 in the study group were higher than those in the control group;the levels in the severe group were higher than those in the moderate and mild groups(P<0.05),and the levels in the moderate group were higher than those in the mild group(P<0.05).Spearman correlation analysis showed that ultrasound-measured LFC and serum CK18M30,CK18-M65,FGFR1 levels were positively correlated with the severity of NAFLD(r=0.651,0.577,0.569,0.613,P<0.05).ROC analysis showed that the AUC of ultrasound-measured LFC combined with serum CK18-M30,CK18-M65 and FGFR1 in the diagnosis of NAFLD was 0.919,which was higher than that of each single indicator(0.811,0.803,0.820,0.837,P<0.05).Conclusion Ultrasound-measured LFC and serum CK18-M30,CK18-M65,FGFR1 levels are elevated in NAFLD patients.All four indicators are closely related to disease severity,and their combined detection shows superior diagnostic value for NAFLD.
作者
陈诗男
吴楠昕
钟荣
宋晶晶
CHEN Shinan;WU Nanxin;ZHONG Rong;SONG Jingjing(Graduate School,Zhejiang Chinese Medical University,Hangzhou,Zhejiang 310000,China;Department of Ultrasound Medicine,Jingning Peoples Hospital,Lishui,Zhejiang 323500,China;Department of Internal Medicine,J ingning Peoples Hospital,Lishui,Zhejiang 323500,China;Department of Interventional Radiology,Lishui Central Hospital,Lishui,Zhejiang 323000,China)
出处
《重庆医学》
2026年第3期538-542,549,共6页
Chongqing Medical Journal
基金
浙江省基础公益研究计划项目(LTGY23H180006)。
