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细胞角蛋白18在非酒精性脂肪性肝病无创评估中的作用 被引量：1

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摘要 随着肥胖和代谢综合征的全球流行,非酒精性脂肪性肝病（non-alcoholic fatty liver disease,NAFLD）已成为欧美等西方发达国家最常见的慢性肝病,普通人群的NAFLD患病率为20%-40%,预计10-20年内,NAFLD将成为终末期肝病、肝移植和肝细胞性肝癌（hepatocellular carcinoma,HCC）的主要病因[1-3]。传统上,肝活检组织学检查仍是目前诊断NAFLD的金标准,该方法除能定量评估肝细胞脂肪变、炎症和纤维化外,
作者 陈一铭 沈峰 范建高
机构地区 上海交通大学医学院附属新华医院消化内科
出处 《诊断学理论与实践》 2014年第2期121-124,共4页 Journal of Diagnostics Concepts & Practice
基金 国家科技部973项目(2012CB517501) 中国肝炎防治基金会王宝恩肝纤维化研究基金(XJS20120501) 上海交通大学医学院附属新华医院院长基金项目(12QYJ05)
关键词 非酒精性脂肪性肝病 无创检查 细胞角蛋白-18片段
分类号 R575.5 [医药卫生—消化系统]
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参考文献25

  • 1.范建高,曾民德.脂肪性肝病[M].2版.北京:人民卫生出版社,2013.
  • 2Bellentani S,Saccoccio G,Masutti F,et al.Prevalence of and risk factors for hepatic steatosis in Northern Italy[J].Ann Intern Med,2000,132(2):112-117.
  • 3范建高,施军平.2011年非酒精性脂肪性肝病流行病学与无创诊断研究进展[J].实用肝脏病杂志,2012,15(2):81-83. 被引量：18
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二级参考文献34

  • 1Das K,Das K,Mukherjee PS,et al. Nonobese population in a developing country has a high prevalence of nonalcoholic fatty liver and significant liver disease. Hepatology,2010,51:1593- 1602.
  • 2Everhart JE,Bambha KM. Fatty liver:Think globally.Hepatology, 2010,51(5): 1491-1493.
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  • 4Neusehwander-Tetri BA. Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis:the central role of nontriglyceride fatty acid metabolites. Hepatology,2010,52:774- 788.
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  • 8Chalasani N,Guo X,Loomba R,et al. Genome-wide association study identifies variants associated with histologic features of nonalcoholic fatty liver disease. Gastroenterology,2010,139: 1567-1576.
  • 9Joka D,Wahl K,Moeller S,et al. Prospective biopsy-controlled evaluation of cell death biomarkers for prediction of liver fibrosis and nonalcoholic steatohepatitis. Hepatology,2012,55: 455-464.
  • 10Musso G,Gambino R,Cssader M,et al. A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease. Hepatology, 2010,52:79-104.

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诊断学理论与实践
2014年 第2期

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