摘要
目的:探讨不同剂量阿司匹林(ASA)对子痫前期(PE)孕产妇预防的效果,及对凝血功能、妊娠结局等的影响。方法:选择2024年1月—2025年2月本院收治的PE高危孕产妇231例作为研究对象,随机分为对照组(n=115)和观察组(n=116)。对照组采用150 mg ASA干预,观察组采用100 mg ASA干预。比较2组血压指标、凝血功能、胎盘血流灌注参数、PE发生率及妊娠结局。结果:对照组凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)水平显著高于观察组(P<0.05),纤维蛋白原(FIB)、收缩压(SBP)、D-二聚体(D-D)、血小板聚集指数、舒张压(DBP)水平显著低于观察组(P<0.05);对照组子宫动脉搏动指数(PI)显著高于观察组(P<0.05),阻力指数(RI)显著低于观察组(P<0.05);对照组PE发生率(13.0%)显著高于观察组(5.2%)(P<0.05);胎盘早剥、产后出血等发生率显著高于观察组(P<0.05)。结论:PE高危孕产妇适当增加ASA使用剂量,凝血功能改善较大,但随着剂量增加,不良妊娠发生风险、PE发生率也随之升高,在临床应用中,需根据孕产妇具体情况谨慎选择。
Objective:To discuss the preventive effect of the different dosages of aspirin(ASA)for the preeclampsia(PE)of pregnant women,and to study its impacts on the coagulation function and the pregnancy outcomes.Methods:A total of 231 pregnant women with high-risk PE who admitted to the hospital were selected as the research subjects and were randomly divided into control group(n=115)and observation group(n=116)from January 2024 to February 2025.The women in the control group were treated with 150 mg ASA,while the women in the observation group were treated with 100 mg ASA.The blood pressure indicators,the coagulation function,the placental blood perfusion parameters,the incidence of PE and the pregnancy outcomes of the women were compared between the two groups.Results:The prothrombin time(PT)and activated partial thromboplastin time(APTT)of the women in the observation group were significantly higher than those of the women in the control group,and the levels of the fibrinogen(FIB),systolic blood pressure(SBP)and D-dimer(D-D),and the values of platelet aggregation index and diastolic blood pressure(DBP)of the women in the observation group were significantly lower than those of the women in the control group(P<0.05).The uterine artery pulsatility index(PI)value of the women in the observation group was significantly higher than that of the women in the control group(P<0.05),and the resistance index(RI)value of the women in the observation group was significantly lower(P<0.05).The incidence of PE(13.0%)of the women in the observation group was significantly higher than that(5.2%)of the women in the control group(P<0.05).The incidences of the placental abruption and the postpartum hemorrhage of the women in the observation group were significantly higher than those of the women in the control group(P<0.05).Conclusion:The increase dosage of ASA is appropriately for the pregnant women with high-risk PE,and which can clearly improve their coagulation function.However,as the dosage increases,the risk of the adverse pregnancy and the incidence of PE of the women also increase.In clinical application,the careful selection should be made according to the specific situation of the pregnant women.
作者
刘营营
李琦
高喜梅
LIU Yingying;LI Qi;GAO Ximei(Obstetric Medicine Center,Cangzhou Central Hospital,No.16 Xinhua West Road,Cangzhou,Hebei Province,061000;Handan Maternal and Child Health Hospital New Screening Center,Handan,Hebei Province 056000;Medical Department of Cangzhou Central Hospital,Cangzhou,,Hebei Province 061000)
出处
《中国计划生育学杂志》
2026年第3期511-515,共5页
Chinese Journal of Family Planning
基金
河北省2025年度医学科学研究课题计划项目(20251561)。
关键词
子痫前期
阿司匹林
剂量
凝血功能
妊娠
Preeclampsia
Aspirin
Dosage
Coagulation function
Pregnancy
