摘要
目的探讨小剂量阿司匹林联合复合维生素对子痫前期(PE)的预防效果及对孕妇妊娠结局的影响。方法回顾性分析我院2014年11月至2019年8月收治的120例PE高危孕妇的病历资料,按照治疗方式的不同将其分为观察组(60例,小剂量阿司匹林+复合维生素)与对照组(60例,常规治疗)。比较两组的凝血功能指标、血压、24 h尿蛋白定量及母婴妊娠结局。结果治疗后,两组的PT、APTT均增加,FIB、D-D水平均降低,且观察组明显优于对照组(P<0.05)。治疗后,两组SBP、DBP及24 h尿蛋白定量均降低,且观察组明显低于对照组(P<0.05)。观察组PE发病率及低体重儿出生率均低于对照组,分娩孕周大于对照组,新生儿Apgar评分高于对照组(P<0.05)。两组肝肾功能损伤率、胎盘早剥发生率、产后出血率及围生期死亡率无显著差异(P>0.05)。结论小剂量阿司匹林联合复合维生素可显著降低PE孕妇血液高凝状态和PE发病率,改善母婴结局,且安全性好。
Objective To explore the preventive effect of low-dose aspirin combined with compound vitamin on preeclampsia(PE)and its influence on pregnancy outcome of pregnant women.Methods The medical records of 120 high-risk PE pregnant women admitted in our hospital from November 2014 to August 2019 were retrospectively analyze.According to different treatment methods,the pregnant women were divided into observation group(60 cases,low-dose aspirin+compound vitamin)and control group(60 cases,routine treatment).The coagulation function indexes,blood pressure,24 h urine protein quantification and maternal and infant pregnancy outcomes were compared between the two groups.Results After treatment,PT and APTT in both groups increased,the levels of FIB and D-D in both groups decreased,and those in the observation group were significantly better than the control group(P<0.05).After treatment,SBP,DBP and 24 h urine protein quantitfication in the two groups decreased,and those in the observation group were significantly lower than the control group(P<0.05).The incidence of PE and birth late of low birth weight infants in the observation group were lower than those in the control group,the delivery pregnancy week was greater than that in the control group,Apgar scores of newborn was higher than that in the control group(P<0.05).There were no significant differences in the rate of liver and kidney function damage,the incidence of placental abruption,the rates of postpartum hemorrhage and the perinatal mortality between the two groups(P>0.05).Conclusion Low-dose aspirin combined with compound vitamin can significantly reduce the blood hypercoagulability of pregnant women with PE and the incidence of PE,improve the maternal and infant outcomes and have good safety.
作者
刘辉
张艳艳
LIU Hui;ZHANG Yan-yan(Huangling People's Hospital,Yan'an 727300,China)
出处
《临床医学研究与实践》
2020年第16期139-141,共3页
Clinical Research and Practice
