摘要
Two new linear furocoumarins were isolated from Notopterygium incisum using silica gel,gel Sephadex LH-20 column chromatography,and preparative high-performance liquid chromatography.The structures of the new compounds were elucidated through analysis of spectroscopic evidence,including data obtained from high-resolution electrospray ionization mass spectrometry(HRESIMS)and nuclear magnetic resonance(NMR).The absolute configurations of Notoprenylate L(1)and Nototerprinol K(2)were further confirmed using electronic circular dichroism(ECD)calculations.Compound 1 demonstrated the ability to inhibit the expression of nitric oxide(NO),a pro-inflammatory factor,in lipopolysaccharide-induced RAW264.7 macrophages at a concentration of 7.5μmol/L,indicating its potential for anti-inflammatory activity.
采用硅胶、凝胶等柱色谱及制备液相色谱从羌活中分离出两个新型的线型呋喃香豆素类化合物.通过高分辨电喷雾电离质谱(HRESIMS)和核磁共振(NMR)等光谱解析了新化合物的结构,并使用电子圆二色谱(ECD)计算进一步确认了NotoprenylateL(1)和NototerprinolK(2)的绝对构型.化合物1在7.5umol/L时可抑制脂多糖诱导的巨噬细胞RAW264.7中炎症因子NO的表达,表现出一定的抗炎活性潜能.
出处
《有机化学》
北大核心
2026年第1期300-303,共4页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.82304887)
四川省科技计划(No.2024ZYD0116)资助项目.
