摘要
吲哚生物碱分布广泛、结构复杂,并且具有丰富的药理活性,是目前天然产物全合成领域的研究热点.生物碱arboridinine和arborisidine是从马来西亚的蕊木属植物中分离得到的,这两个生物碱特殊而高度复杂的笼状结构使其全合成研究极具挑战性,因此得到了广泛关注.本文总结了arboridinine和arborisidine的全合成研究进展,以期为相关天然产物的全合成提供参考.
Indole alkaloids are widely distributed in nature and have rich pharmacological activities,so many indole alkaloids have emerged as hot targets for the total synthesis of natural products.The alkaloids arboridinine and arborisidine were isolated from a plant of the Kopsia genus found in Malaysia by Kam and co-workers in 2015 and 2016,respectively.These two pentacyclic monoterpenoid indole alkaloids have unique caged skeleton with multiple chiral centers.The highly complex cage structure of these alkaloids has brought great challenges to their total synthesis research.In addition,arborisidine combined with pimelautide exhibits clear anti-gastric cancer activity.The complex and attractive chemical structure and potential pharmacological activity,together with an extremely low natural abundance make their total synthesis extremely attractive.Soon after the isolation,their total synthesis has received extensive and sustained attention.Up to now,the total synthesis of arboridinine has be achieved by the Snyder,Ma,Zhai and Li groups,and the total synthesis of arborisidine by the Snyder,Ma,Zhu,Jiao,She and Gao groups.This review summarizes the research progress of total synthesis of arboridinine and arborisidine,in order to provide reference for the total synthesis of the related natural products.
作者
何卫刚
段明月
闫帅
叶伟杰
徐雪园
孙先宇
He Weigang;Duan Mingyue;Yan Shuai;Ye Weijie;Xu Xueyuan;Sun Xianyu(School of Biology and Food Engineering,Suzhou University of Technology,Changshu,Jiangsu 215500;School of Pharmacy,China Pharmaceutical University,Nanjing 210009)
出处
《有机化学》
北大核心
2026年第2期443-454,共12页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.22401019)资助项目。
