摘要
肝硬化失代偿期病人中衰弱普遍存在。其发病机制可能与营养不良、高氨血症、全身慢性炎症、激素代谢紊乱、肠道菌群失调、肝硬化并发症与非肝因素等有关。通过定期评估病人功能状态,动态监测营养指标以早期识别衰弱,并予以及时的营养干预、体能锻炼和药物治疗,可有效改善病人预后、降低死亡率、提高病人生存质量。本文就肝硬化失代偿期衰弱的发病机制及治疗的研究进展做一简要综述。
Frailty is common in patients with decompensated cirrhosis.with its pathogenesis potentially linked to malnutrition,hyperammonaemia,systemic chronic inflammation,hormonal dysregulation,gut microbiota dysbiosis,and complications of liver cirrhosis and non-hepatic factors.Frailty is preventable,delayable,and potentially reversible.Regular functional assessments and dynamic monitoring of nutritional indicators can facilitate early frailty identification.Timely interventions,including nutritional support,physical exercise,and medication,can enhance patient prognosis,reduce mortality,and improve quality of life.This review briefly reviews the research progress on the pathogenesis and treatment of frailty in decompensated liver cirrhosis.
作者
张福桃
张雅乐
孙圆圆
陈平
杜春
ZHANG Fu-tao;ZHANG Ya-le;SUN Yuan-yuan;CHEN Ping;DU Chun(Department of Gastroenterology,The First Hospital of Qiqihar,Qiqihar 161000,Heilongjiang,China;Department of Critical Care Medicine,Zhungeer Banner Central Hospital,Ordos 010300,Inner Mongolia,China;Department of Gastroenterology,Zhungeer Banner Central Hospital,Ordos 010300,Inner Mongolia,China;Department of Gastroenterology,Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,Inner Mongolia,China)
出处
《肠外与肠内营养》
北大核心
2026年第1期51-57,共7页
Parenteral & Enteral Nutrition
基金
内蒙古医科大学联合项目(YKD2024LH013)。
关键词
肝硬化失代偿期
衰弱
发病机制
干预措施
Decompensated cirrhosis
Frailty
Pathogenesis
Intervention measures
