摘要
目的探讨新诊断2型糖尿病(type 2 diabetes mellitus,T2DM)患者多种脂蛋白–尿酸比值与非酒精性脂肪肝病(non-alcoholic fatty liver disease,NAFLD)的相关性。方法选取2024年4月至2025年6月在安徽医科大学第一附属医院住院的138例新诊断T2DM患者作为研究对象,依据腹部超声结果分为NAFLD组(n=106)与非NAFLD组(n=32)。收集患者的一般资料与生化指标,计算总胆固醇/高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、甘油三酯(triglyceride,TG)/HDL-C、低密度脂蛋白胆固醇/HDL-C、尿酸/HDL-C、TG/载脂蛋白(apolipoprotein,Apo)A1五种脂蛋白比值。采用多因素Logistic回归分析影响因素,通过受试者操作特征曲线(receiver operating characteristic curve,ROC曲线)评估其预测性能。结果多因素Logistic回归分析结果显示,在调整性别、年龄、体质量指数、血糖及肝功能等多种混杂因素后,所有脂蛋白比值均与NAFLD独立正相关(P<0.05)。ROC曲线分析显示,五种脂蛋白比值均对NAFLD有良好的预测价值,其中TG/ApoA1的曲线下面积最大,为0.846(95%CI:0.767~0.925)。结论在新诊断T2DM患者中,五种脂蛋白比值均与NAFLD存在独立正相关,且对NAFLD具有良好的预测效能。TG/ApoA1比值展现出突出的预测潜力,具备作为临床筛查生物标志物的应用价值。
Objective To investigate the association and predictive value of various lipoprotein ratios with nonalcoholic fatty liver disease(NAFLD)in newly diagnosed type 2 diabetes mellitus(T2DM)patients.Methods A total of 138 newly diagnosed T2DM patients hospitalized at the First Affiliated Hospital of Anhui Medical University from April 2024 to June 2025 were selected as subjects.Based on abdominal ultrasound findings,they were divided into NAFLD group(n=106)and non-NAFLD group(n=32).General information and biochemical indicators were collected from the patients.Five lipid ratios were calculated:total cholesterol/high-density lipoprotein cholesterol(HDL-C),triglyceride(TG)/HDL-C,low-density lipoprotein cholesterol/HDL-C,uric acid/HDL-C,and TG/apolipoprotein(Apo)A1.Multivariate logistic regression analysis was performed to identify influencing factors,and the predictive performance was evaluated using the receiver operating characteristic(ROC)curve.Results Multivariate Logistic regression analysis revealed that all lipoprotein ratios were independently and positively correlated with NAFLD after adjustment for confounding factors such as sex,age,body mass index(BMI),blood glucose,and liver function(P<0.05).ROC curve analysis demonstrated that all five lipoprotein ratios had good predictive value for NAFLD,with TG/ApoA1 exhibiting the highest area under the curve(AUC)of 0.846(95%CI:0.767-0.925).Conclusion In newly diagnosed patients with T2DM,all five lipoprotein ratios exhibited independent positive correlations with NAFLD and demonstrated strong predictive value for NAFLD.The TG/ApoA1 ratio showed outstanding predictive potential and holds application value as a clinical screening biomarker.
作者
周心怡
姚骏骁
王莲子
臧艳
申梦娇
李涛
ZHOU Xinyi;YAO Junxiao;WANG Lianzi;ZANG Yan;SHEN Mengjiao;LI Tao(Department of Clinical Laboratory,the First Affiliated Hospital of Anhui Medical University,Hefei 230032,Anhui,China)
出处
《中国现代医生》
2026年第5期34-38,共5页
China Modern Doctor
基金
安徽医科大学横向课题项目(K2023009)。
关键词
2型糖尿病
非酒精性脂肪肝
脂蛋白比值
尿酸
预测价值
Type 2 diabetes mellitus
non-alcoholic fatty liver disease
Lipoprotein ratios
Uric acid
Predictive value
