摘要
近年来关于肠道菌群与非酒精性脂肪肝疾病关系的研究越来越多。非酒精性脂肪肝是一种无过量饮酒史,肝内脂肪过量堆积的慢性疾病。生理解剖结构上的"肠-肝轴"表明肠道和肝脏有着密不可分的关系。肠道菌群一般情况下处于动态平衡,可以维持肠道正常生理功能。肠道菌群可通过改善肠道通透性、干预脂质代谢、产生内源性乙醇和产生短链脂肪酸等来影响非酒精性脂肪肝疾病的发生与发展。临床上对于治疗非酒精性脂肪肝没有确切的药物,增加有益肠道菌群的因素,如益生元、益生菌等能够调节肠道的微环境,这为非酒精性脂肪肝疾病的治疗开辟了新的方向。
In recent years,more and more studies have been conducted on the relationship between intestinal flora and non-alcoholic fatty liver disease(NAFLD).NAFLD is a chronic disease with no history of excessive alcohol consumption and excessive accumulation of fat in liver.The"enter-hepatic axis"on the anatomy indicates that the intestinal and liver are closely related.Intestinal flora in general under the dynamic balance,can maintain the normal physiological function of the intestinal.Intestinal flora can affect the occurrence and development of NAFLD by improving intestinal permeability,intervening lipid metabolism,producing endogenous ethanol and producing short-chain fatty acids.Clinically,there is no specific drug for the treatment of NAFLD,and the increase of beneficial intestinal flora,such as probiotics and probiotics,can regulate the intestinal microenvironment,which opens a new direction for the treatment of NAFLD.
作者
单蕊
陈燕
姚政
SHAN Rui;CHEN Yan;YAO Zheng(Yunnan College of Traditional Chinese Medicine,Kunming,Yunnan 650500,China)
出处
《中国微生态学杂志》
CAS
CSCD
2019年第7期841-843,共3页
Chinese Journal of Microecology
基金
国家自然科学基金[参苓白术散“健脾益气”治疗非酒精性脂肪肝的作用机理研究”(81860812)]
云南省应用基础研究-中医联合专项:健脾方药对脂肪肝细胞炎症反应微环境影响的初步研究[2017FF116(-021)]
关键词
肠道菌群
非酒精性脂肪肝病
益生元
益生菌
Intestinal flora
Non-alcoholic fatty liver disease
Prebiotics
Probiotics
