摘要
目的探讨氧化应激与青少年首发抑郁障碍患者发病、认知功能损伤的关系。方法2022年7月至2024年6月纳入130例在郑州大学第一附属医院就诊的青少年首发抑郁障碍患者(抑郁障碍组)和118例青少年体检志愿者(健康对照组)。检测两组氧化应激相关标志物总胆红素(TBIL)、白蛋白(ALB)、同型半胱氨酸(Hcy)、尿酸(UA)、血清氧化型谷胱甘肽(GSSG)、还原型谷胱甘肽(GSH)、一氧化氮(NO)和超氧化物歧化酶(SOD)浓度;采用认知功能成套测验(MCCB)中文版评定被试认知功能。使用SPSS 22.0软件进行卡方检验、独立样本t检验和偏相关分析。结果(1)外周血生化指标检测结果显示,抑郁障碍组青少年外周血Hcy、UA、GSSG浓度均高于健康对照组(t=6.234,2.405,7.897,均P<0.05),GSH、GSH/GSSG比值、SOD浓度均低于健康对照组(t=-6.822,-8.238,-5.866,均P<0.05)。(2)MCCB的7个认知领域评估结果显示,抑郁障碍组信息处理速度评分[(38.09±10.52)分,(46.98±7.72)分,t=-7.633,P<0.001]、注意及警觉性评分[(38.69±10.43)分,(48.33±10.01)分,t=-7.410,P<0.001]、词语学习评分[(38.38±9.39)分,(45.86±10.10)分,t=-6.048,P<0.001]、视觉学习评分[(36.08±13.75)分,(49.08±8.07)分,t=-9.180,P<0.001]、工作记忆评分[(39.90±8.97)分,(49.75±7.87)分,t=-9.145,P<0.001]、推理和问题解决评分[(37.62±9.66)分,(48.12±10.03)分,t=-8.393,P<0.001]、社会认知评分[(35.05±8.64)分,(44.34±11.26)分,t=-7.239,P<0.001]均低于健康对照组。(3)相关分析结果显示,抑郁障碍组Hcy水平与信息处理速度评分、工作记忆评分均呈负相关(r=-0.292,-0.178,均P<0.05),GSSG水平与推理和问题解决评分呈负相关(r=-0.188,P<0.05),GSH/GSSG比值与推理和问题解决评分呈正相关(r=0.278,P=0.002),SOD水平与工作记忆评分呈正相关(r=0.210,P<0.05)。结论氧化应激可能参与青少年抑郁障碍的发病并且与患者认知功能损伤有关。
Objective To explore the relationship between oxidative stress and onset and cognitive impairment in adolescent patients with first-episode depression.Methods A total of 130 adolescent patients with first-episode depression(depression group)from the First Affiliated Hospital of Zhengzhou University and 118 healthy control participants(healthy control group)were recruited from July 2022 to June 2024.The oxidative stress-related markers,including total bilirubin(TBIL),albumin(ALB),homocysteine(Hcy),uric acid(UA),oxidized glutathione(GSSG),glutathione(GSH),nitric oxide(NO),and superoxide dismutase(SOD),were detected in the two groups.The Chinese version of the MATRICS consensus cognitive battery(MCCB)was used to assess cognitive function.SPSS 22.0 software was used for chi-square test,independent sample t-test,and partial correlation analysis.Results(1)The results of peripheral blood biochemical indices showed that the levels of Hcy,UA,and GSSG in depression group were higher than those in the healthy control group(t=6.234,2.405,7.897,all P<0.05),while the levels of GSH,GSH/GSSG ratio,and SOD were lower than those in the healthy control group(t=-6.822,-8.238,-5.866,all P<0.05).(2)The evaluation results of 7 cognitive domains of MCCB showed that the information processing speed score(38.09±10.52,46.98±7.72,t=-7.633,P<0.001),attention and alertness score(38.69±10.43,48.33±10.01,t=-7.410,P<0.001),word learning score(38.38±9.39,45.86±10.10,t=-6.048,P<0.001),visual learning score(36.08±13.75,49.08±8.07,t=-9.180,P<0.001),working memory score(39.90±8.97,49.75±7.87,t=-9.145,P<0.001),reasoning and problem-solving score(37.62±9.66,48.12±10.03,t=-8.393,P<0.001),social cognition score(35.05±8.64,44.34±11.26,t=-7.239,P<0.001)in the depression group were all lower than those in the healthy control group.(3)The correlation analysis results showed that the Hcy level in the depression group was negatively correlated with information processing speed score and working memory score respectively(r=-0.292,-0.178,both P<0.05),GSSG level was negatively correlated with reasoning and problem-solving score(r=-0.188,P<0.05),GSH/GSSG ratio was positively correlated with reasoning and problem-solving score(r=0.278,P=0.002),and SOD level was positively correlated with work memory score(r=0.210,P<0.05).Conclusion Oxidative stress may be involved in the onset of adolescent depression and is associated with cognitive impairment in patients.
作者
杨磊
牛琪惠
连楠
牛朋涛
王猛
王琼
郝以辉
Yang Lei;Niu Qihui;Lian Nan;Niu Pengtao;Wang Meng;Wang Qiong;Hao Yihui(Department of Psychiatry,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Department of Physical Examination,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
出处
《中华行为医学与脑科学杂志》
北大核心
2026年第2期121-126,共6页
Chinese Journal of Behavioral Medicine and Brain Science
基金
河南省科技攻关计划(242102311050,252102311006)。
关键词
抑郁障碍
氧化应激
认知功能
青少年
Depressive disorder
Oxidative stress
Cognitive function
Adolescent
