摘要
BACKGROUND Cognitive impairment is one of the common clinical manifestations of depression,causing negative distress to patients.Elevated homocysteine(Hcy)concentrations and gut microbiome dysfunction may be observed in patients with depression.AIM To investigate the relationship between Hcy,microbiome,and cognition in depressive patients.METHODS We recruited 67 patients with major depressive disorder(MDD)(MDD group)and 94 healthy controls(HCs)individuals(HCs group).Serum Hcy levels were determined using the enzyme circulation method.16s rRNA sequencing was used to classify and identify the fecal bacteria.17 Hamilton depression rating scale and MATRICS consensus cognitive battery were used to evaluate mood states and cognition in patients with MDD. Correlation analysis was performed to explore the correlation between fecal flora,Hcy, and depressive cognitive function.RESULTSElevated serum levels of Hcy were seen in patients with MDD compared to healthy individuals. Patients withMDD indicated significant decreases in cognitive scores (P < 0.001) in six modules: Speed of processing, workingmemory, visual learning, reasoning and problem-solving, social cognition, and total scores. Hcy levels showed anegative correlation with processing speed, social cognition, and total MDD scores (P < 0.05). Hcy was alsosignificantly negatively correlated with Alistipes, Ruminococcae, Tenericides, and Porphyromonas (P < 0.05).CONCLUSIONOur results highlight that Hcy was correlated with cognition and gut microbiome in MDD. This interaction may berelated to the physiological and pathological mechanisms underlying cognitive deficits in depression.
基金
Supported by the Wuxi Municipal Health Commission Youth Fund Project,No.Q202268
Wuxi Scientific and technological breakthrough of“Light of the Taihu Lake”(Basic Research),No.K20221039
Jiangsu Shuangchuang Doctoral Program,No.JSSCBS20221991
Beijing Municipal Administration of Hospital Incubating Program,No.PX2023070 and No.PX2024072
Capital’s Funds for Health Improvement and Research,No.SF2024-4-2134
Beijing Hospitals Authority Youth Program,No.QML20232003
the Top Talent Support Program for young and middle-aged people of Wuxi Health Committee,No.HB2023089.
