摘要
四氢生物蝶呤作为芳香族氨基酸羟化酶的重要辅酶,参与体内氨基酸的代谢。以其为基础研制的药品盐酸沙丙蝶呤片已获批用于高苯丙氨酸血症患者的治疗。近年来,随着对盐酸沙丙蝶呤研究的不断深入,发现该药可有效降低高苯丙氨酸血症患者体内苯丙氨酸浓度,改善高苯丙氨酸血症患者症状,降低并发症风险,但其长期应用安全性仍有待进一步研究和评估。目前国内对将盐酸沙丙蝶呤片作为四氢生物蝶呤替代品治疗高苯丙氨酸血症的研究相对较少。该文旨在综述国内外相关研究进展,为盐酸沙丙蝶呤片临床应用提供参考。
Tetrahydrobiopterin,as an important coenzyme of aromatic amino acid hydroxylase,is involved in the metabolism of amino acids in the body.Based on that mechanism,the drug sapropterin hydrochloride tablet has been approved for the treatment of patients with hyperphenylalaninemia.In recent years,with the further research on the application of the drug,it has been found that sapropterin hydrochloride tablets can effectively reduce the concentration of phenylalanine in patients with hyperphenylalaninemia,improve the symptoms of patients with hyperphenylalaninemia,and reduce the risk of complications.But its long-term safety still needed further studies and evaluation.At present,there are relatively few studies on sapropterin hydrochloride tablets as an alternative to tetrahydrobiopterin in the treatment of hyperphenylalaninemia in China.This review aims to integrate relevant studies at home and abroad to provide a reference for the clinical application of sapropterin hydrochloride tablets.
作者
辛玟
于飞
XIN Wen;YU Fei(Training Base of Maternal and Child Health Hospital of Hubei Province,Hubei University of Medicine,Wuhan 430070,China;Department of Child Endocrinology and Genetic Metabolism,Maternal and Child Health Hospital of Hubei Province,Wuhan 430070,China)
出处
《医药导报》
北大核心
2026年第3期494-499,共6页
Herald of Medicine
关键词
盐酸沙丙蝶呤片
高苯丙氨酸血症
四氢生物蝶呤
苯丙氨酸
Sapropterin hydrochloride tablets
Hyperphenylalaninemia
Tetrahydrobiopterin
Phenylalanine
