摘要
膀胱癌是常见且易复发的泌尿系统恶性肿瘤, 尤其在肌层浸润及转移性病例中, 传统手术、化疗及免疫治疗常面临疗效有限和系统毒性大的挑战。近年来, 依赖活性氧生成的动态治疗因其高选择性和良好安全性备受关注。其中, 声动力治疗凭借超声优异的组织穿透性与空间可控性, 被视为突破光动力治疗局限的理想策略。其通过声敏剂在超声激发下产生活性氧, 诱导肿瘤细胞死亡, 实现高效选择性杀伤。本综述总结了声动力治疗的作用机制及其在膀胱癌治疗中的研究进展, 重点介绍基于纳米技术的增强策略, 包括声敏剂优化、氧供调控及联合治疗等方案, 并探讨其临床转化的挑战与前景。综上, 声动力治疗有望为膀胱癌精准治疗提供新方向。
Bladder cancer is a common urological malignancy with a high risk of recurrence.In cases of muscle-invasive or metastatic disease,traditional therapies such as surgery,chemotherapy,and immunotherapy often face limitations in efficacy and are associated with considerable systemic toxicity.In recent years,dynamic therapeutic strategies that generate reactive oxygen species(ROS)have attracted increasing attention due to their high selectivity and favorable safety profile.Among them,sonodynamic therapy(SDT),benefiting from the superior tissue penetration and spatial controllability of ultrasound,is regarded as a promising alternative to overcome the penetration depth limitation of photodynamic therapy.By activating sonosensitizers under ultrasound irradiation to produce ROS,SDT induces tumor cell apoptosis,necrosis,or immunogenic cell death,enabling selective and efficient tumor eradication.This review summarizes the mechanisms of SDT and recent advances in its application to bladder cancer.Furthermore,nanotechnology‐enhanced strategies—including sonosensitizer optimization,oxygen supply regulation,and combination therapies—are highlighted,along with current challenges and future prospects in clinical translation.In conclusion,SDT shows great potential as a novel approach for precision treatment of bladder cancer.
作者
张云华
周青
余伟民
阮远
Zhang Yunhua;Zhou Qing;Yu Weimin;Ruan Yuan(Department of Ultrasound,Renmin Hospital of Wuhan University,Wuhan 430060,China;Department of Urology,Renmin Hospital of Wuhan University,Wuhan 430060,China)
出处
《中华实验外科杂志》
2026年第1期199-203,共5页
Chinese Journal of Experimental Surgery
关键词
声动力治疗
声动力化疗
膀胱癌
肿瘤微环境
研究进展
Sonodynamic therapy
Sonodynamic chemotherapy
Bladder cancer
Tumor microenvironment
Research progress
