摘要
目的 探讨百笑灸对绝经后骨质疏松症(postmenopausal osteoporosis,PMOP)患者中医证候积分、总有效率、1型胶原交联羧基端肽(β-CTX)、1型原胶原氨基端前肽(P1NP)、骨钙素(BGP)、25羟维生素D(25OHD)、甲状旁腺素(PTH)及骨密度(BMD)的影响。方法 将68例PMOP患者随机分为对照组和试验组,每组34例。对照组予以常规西药治疗(伊班膦酸钠+云克);试验组在此基础上叠加百笑灸治疗。观察两组患者治疗前后中医证候积分、β-CTX、P1NP、BGP、25OHD、PTH及BMD的变化,对比临床疗效。结果 (1)两组患者治疗后,中医证候积分均显著下降(P<0.001),且试验组优于对照组(P<0.001)。5项中医证候评分,试验组均表现出显著改善(P<0.05)。试验组总有效率(90.9%)优于对照组(75.8%);(2)两组患者治疗后,β-CTX、P1NP、BGP均显著下降(P<0.001),且试验组优于对照组(P<0.05);(3)两组患者治疗后,25OHD均增加(P<0.001),且试验组高于对照组(P=0.040);(4)两组患者治疗后,对照组PTH升高(P<0.001),试验组PTH下降(P<0.001),试验组低于对照组(P=0.041);(5)两组患者治疗后及组间,腰椎及全髋BMD差异均无统计学意义(P>0.05)。结论 百笑灸对PMOP患者有辅助治疗作用,有助于缓解患者临床症状,抑制骨吸收,降低骨折风险,并提升患者的维生素D水平。
Objective To investigate the effects of Happyall moxibustion on traditional Chinese medicine(TCM)syndrome scores,total effective rate,βisomer of C-terminal telopeptide of type 1 collagen(β-CTX),procollagen type 1 N-terminal propeptide(P1NP),Bone Gla Protein(BGP),25-hydroxyvitamin D(25OHD),parathyroid hormone(PTH)and bone mineral density(BMD)in postmenopausal osteoporosis(PMOP)patients.Methods Sixty-eight patients with PMOP were randomly divided into a control group and an experimental group,with 34 patients in each group.The control group received conventional western medicine treatment(Sodium Ibandronate Injection+Cloud G).The experimental group received Happyall moxibustion treatment.Changes in TCM syndrome scores,β-CTX,P1NP,BGP,25OHD,PTH,and BMD were observed before and after treatment in both groups,and clinical efficacy was compared.Results①After treatment,TCM syndrome scores decreased significantly in both groups(P<0.001),and the experimental group performed better than the control group(P<0.001).The scores of five TCM syndromes,the experimental group showed significant improvement(P<0.05).The total effective rate in the experimental group(90.9%)was higher than that in the control group(75.8%);②After treatment,β-CTX,P1NP,and BGP decreased significantly in both groups(P<0.001),and the experimental group performed better than the control group(P<0.05);③ After treatment,25OHD increased in both groups(P<0.001),and the level in the experimental group was higher than that in the control group(P=0.040);④After treatment,PTH decreased in the experimental group(P<0.001),increased in the control group(P<0.001),and was lower in the experimental group than in the control group(P=0.041);⑤ There were no statistically significant differences in lumbar spine and total hip BMD between the two groups after treatment and between groups(P>0.05).Conclusion Happyall moxibustion has an adjuvant therapeutic effect on patients with PMOP.It helps to alleviate clinical symptoms,inhibit bone resorption,reduce the risk of fractures,and improve patients'vitamin D status.
作者
吴雅珍
詹陈菊
唐欧风
韦翠花
叶羽翀
WU Yazhen;ZHAN Chenju;TANG Oufeng;WEI Cuihua;YE Yuchong(Mindong Hospital of Ningde City,Fuan 355000,China;West China Hospital,Sichuan University,Chengdu 610041,China)
出处
《中国骨质疏松杂志》
北大核心
2026年第2期199-204,共6页
Chinese Journal of Osteoporosis
基金
福建省自然科学基金资助项目(2021J011446)。
