摘要
目的探究低频重复经颅磁刺激(rTMS)联合光照疗法,对青少年季节性抑郁伴随非自杀性自伤(NSSI)行为的治疗成效。方法前瞻性选取2023年10月到2025年1月120例季节性抑郁伴NSSI行为的青少年患者,应用随机数字表法分为2组,对照组60例展开rTMS治疗,研究组60例展开rTMS联合光照疗法。比较2组抑郁症状改善情况,自伤行为及冲动行为改善情况,血清标志物,不良反应情况。结果治疗后,研究组躯体症状、情感缺失、社交退缩、自我评价、负性情绪、儿童抑郁量表总分,和渥太华自伤调查表评分、Barratt冲动型量表第11版无计划冲动、运动冲动、注意力冲动维度评分均低于对照组(P<0.05);治疗后,研究组多巴胺、5-羟色胺、脑源性神经营养因子水平高于对照组,微小核糖核酸-124相对表达量低于对照组(P<0.05);2组不良反应发生率比较差异无统计学意义(P>0.05)。结论rTMS联合光照疗法对青少年季节性抑郁伴NSSI行为效果显著,可改善患者抑郁症状,自伤行为及冲动行为,改善血清相关标志物水平,且安全性高。
Objective To explore the effect of low-frequency repetitive transcranial magnetic stimulation(rTMS)combined with light therapy on seasonal depression associated with non-suicidal self-injury(NSSI)in adolescents.Methods A total of 120 adolescent patients with seasonal depression accompanied by NSSI behavior from October 2023 to January 2025 were prospectively selected and divided into 2 groups using the random number table method.Sixty cases in the control group received rTMS treatment,and 60 cases in the study group received rTMS combined with light therapy.The improvement of depressive symptoms,the improvement of self-harming behaviors and impulsive behaviors,serum markers and adverse reactions were compared between the two groups.Results After treatment,the physical symptoms,emotional deficiency,social withdrawal,self-evaluation,negative emotions,and the total score of the Childhood Depression Scale,and the scores of the Ottawa Self-harm Questionnaire,the dimensions of unplanned impulse,motor impulse and attention impulse in the Barratt Impulsi-veness Scale 11 of the study group were all lower than those in the control group(P<0.05).After treatment,the levels of dopamine,serotonin and brain-derived neurotrophic factor in the study group were higher than those in the control group,while the relative expression level of microRNA-124 was lower than that in the control group(P<0.05).Upon comparison,no statistically significant disparity was observed in the occurrence rate of adverse reactions between the two groups(P>0.05).Conclusion rTMS combined with phototherapy has a significant effect on adolescent seasonal depression with NSSI behavior,improving depressive symptoms,self-injury behavior,and impulsive behavior,improving serum-related marker levels,and has high safety.
作者
董召
邵新月
乔云云
侯英杰
Dong Zhao;Shao Xinyue;Qiao Yunyun;Hou Yingjie(Department of Child and Adolescent Psychology I,The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People′s Hospital),Henan 463000,China)
出处
《山西医药杂志》
2026年第3期174-178,共5页
Shanxi Medical Journal
关键词
经颅磁刺激
光照疗法
青少年
季节性抑郁
非自杀性自伤行为
Transcranial magnetic stimulation
Phototherapy
Teenagers
Seasonal depression
Suicidal self-injury
