摘要
目的:观察紫荆止痛贴治疗湿热痹阻型膝关节炎(KOA)的临床疗效。方法:纳入2023年7月—2025年4月广州市中西医结合医院收治的100例KOA患者,按随机数字表法分为对照组与观察组各50例。对照组采用塞来昔布胶囊治疗,观察组在对照组基础上加用紫荆止痛贴治疗,连续治疗4周。比较2组治疗前后骨关节炎指数评分(WOMAC)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、中医证候评分及步行速度变化,以及临床疗效和不良反应发生率。结果:治疗后,观察组总有效率为94.00%(47/50),对照组为82.00%(41/50),组间比较,差异有统计学意义(P<0.05)。治疗后,2组WOMAC评分均较治疗前降低(P<0.05),且观察组评分低于对照组(P<0.05)。治疗后,2组TNF-α、IL-6水平均较治疗前降低(P<0.05),且观察组TNF-α、IL-6水平低于对照组(P<0.05)。治疗后,2组关节肿痛、关节皮温、关节屈伸不利、舌脉象等中医证候评分均较治疗前降低(P<0.05),且观察组各项评分均低于对照组(P<0.05)。治疗后,2组步行速度均较治疗前升高(P<0.05),且观察组步行速度大于对照组(P<0.05)。治疗期间,观察组不良反应发生率为10.00%(5/50),对照组为12.00%(6/50),组间比较,差异无统计学意义(P>0.05)。结论:紫荆止痛贴治疗湿热痹阻型KOA可提高临床疗效,有效降低机体炎症反应,缓解膝关节肿胀、疼痛、活动受限等症状,改善膝关节功能及步行速度。
Objective:To observe the clinical efficacy of Zijing Zhitong Cataplasm in the treatment of knee osteoarthritis(KOA)of dampness-heat blockage type.Methods:A total of 100 patients with KOA admitted to Guangzhou Hospital of Integrated Traditional and West Medicine from July 2023 to April 2025 were enrolled and divided into the control group and the observation group using the random number table method,with 50 cases in each group.The control group was treated with Celecoxib Capsules,while the observation group received Zijing Zhitong Cataplasm in addition to the control group's treatment.The treatment course for both groups was four weeks continuously.The changes in Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)score,interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),traditional Chinese medicine syndrome scores,walking speed before and after treatment,as well as clinical efficacy and incidence of adverse reactions were compared between the two groups.Results:After treatment,the total effective rate was 94.00%(47/50)in the observation group and 82.00%(41/50)in the control group,with a statistically significant difference between the two groups(P<0.05).After treatment,the WOMAC scores of both groups decreased compared with those before treatment(P<0.05),and the score of the observation group was lower than that of the control group(P<0.05).After treatment,the levels of TNF-αand IL-6 in both groups decreased compared with those before treatment(P<0.05),and the levels of TNF-αand IL-6 in the observation group were lower than those in the control group(P<0.05).After treatment,the traditional Chinese medicine syndrome scores for joint swelling and pain,skin temperature around the joint,limited flexion and extension of the joint,and tongue manifestation and pulse condition in both groups decreased compared with those before treatment(P<0.05),and all scores in the observation group were lower than those in the control group(P<0.05).After treatment,the walking speed of both groups increased compared with that before treatment(P<0.05),and the walking speed of the observation group was greater than that of the control group(P<0.05).During treatment,the incidence of adverse reactions was 10.00%(5/50)in the observation group and 12.00%(6/50)in the control group,with no statistically significant difference between the two groups(P>0.05).Conclusion:Zijing Zhitong Cataplasm in the treatment of KOA of dampness-heat blockage type can improve clinical efficacy,effectively reduce systemic inflammatory response,alleviate symptoms such as knee swelling,pain,and limited movement,and improve knee function and walking speed.
作者
郭浩
侯大标
赵荘林
冯永辉
罗东斌
GUO Hao;HOU Dabiao;ZHAO Zhuanglin;FENG Yonghui;LUO Dongbin(Guangzhou University of Chinese Medicine,Guangzhou Guangdong 510405,China;Guangzhou Hospital of Integrated Traditional and West Medicine,Guangzhou University of Chinese Medicine,Guangzhou Guangdong 510800,China)
出处
《新中医》
2026年第4期28-32,共5页
New Chinese Medicine
基金
广东省中医药局基金项目(20242071)
广东省医学科学技术研究基金项目(A2020347)
广州市卫健委资助项目[1010011920(2100601)]
广州市花都区基础与应用基础研究区院联合资助项目(23-HDOYLH-20)。
关键词
膝关节炎
湿热痹阻
塞来昔布胶囊
紫荆止痛贴
骨关节炎指数评分
炎症因子
Knee osteoarthritis
Dampness-heat blockage
Celecoxib Capsules
Zijing Zhitong Cataplasm
WOMAC score
Inflammatory factors
