摘要
子痫前期(PE)是一种妊娠期特有的多系统功能障碍综合征,全球发病率约为2%~8%,是孕产妇及围产儿死亡的主要原因之一。PE的典型病理特征包括胎盘缺血、血管内皮功能障碍及全身炎症反应,但现有机制假说(如滋养细胞侵袭异常、免疫失调等)难以全面解释PE的异质性和多器官受累特征。近年来,细胞间通信网络失衡被认为是PE病理进程的枢纽环节。本文系统阐述了旁分泌信号、外泌体、间隙连接、免疫突触等细胞间通信模式在PE中的异常机制,并探讨了基于通信调控的新型诊疗策略,旨在为PE的机制解析和精准干预提供新视角。
Preeclampsia(PE)is a pregnancy-specific multisystem disorder with a global incidence of approximately 2%to 8%,remaining a leading cause of maternal and perinatal morbidity and mortality.The characteristic pathological PE features include placental ischemia,endothelial dysfunction,and systemic inflammation.However,prevailing hypotheses,such as abnormal trophoblast invasion and immune dysregulation,do not fully account for PE-related clinical heterogeneity and multiorgan involvement.Recently,intercellular communication network disruption has become increasingly recognized as a central driving mechanism of pathophysiological PE progression.In this study,we systematically summarized the aberrant mechanisms of various intercellular communication modes in PE,including paracrine signaling,extracellular vesicles,gap junctions,and immunological synapses.Moreover,we discussed emerging diagnostic and therapeutic strategies for targeting these pathways.In this study,we aimed to provide new perspectives for elucidating PE pathogenesis and for developing precise interventions.
作者
陈炳南
乔宠
CHEN Bingnan;QIAO Chong(Department of Obstetrics and Gynecology,Shengjing Hospital of China Medical University,Shenyang 110022,China)
出处
《中国医科大学学报》
北大核心
2026年第2期97-102,共6页
Journal of China Medical University
基金
国家重点研发计划(2023YFC2705900)
国家自然科学基金(81370735,81771610)
辽宁省民生科技计划联合计划(2021JH2/10300123)
沈阳市科技计划(20-205-4-004)
兴辽英才计划(XLYC2005008)。
关键词
子痫前期
细胞间通信
疾病预测
治疗策略
preeclampsia
intercellular communication
disease prediction
therapeutic strategy
