摘要
目的探讨口服替吉奥胶囊导致胃癌患者重症间质性肺炎的不良反应,为临床安全用药提供参考。方法对1例口服替吉奥治疗胃癌过程中出现重症间质性肺炎的临床资料进行分析,并对国内外相关文献进行回顾总结。结果本例患者重启替吉奥治疗3 d出现发热伴恶心呕吐,胸部CT示双肺间质性肺炎症状较1周前加重,经多学科会诊讨论及关联性分析判断间质性肺炎为替吉奥所致,停用替吉奥,给予甲泼尼龙及呼吸机辅助通气治疗,患者逐渐改善。结论替吉奥致间质性肺炎虽罕见,但可能导致严重的呼吸衰竭而危及生命。临床使用替吉奥应注意药品不良反应,做好用药评估。若患者出现发热、呼吸困难等症状,应及时完善相关检查,根据间质性肺炎分级采取相应的处理措施,改善患者预后。
Objective To analyze such adverse reactions as severe interstitial lung disease(ILD)caused by S-1(tegafur gimeracil oteracil potassium)capsules in a patient with gastric cancer,and to provide a reference for clinicians.Methods The clinical data of a patient who developed ILD during the treatment of her gastric cancer with oral S-1 was analyzed.The related literature was reviewed and summarized.Results The patient developed fever accompanied by nausea and vomiting three days into the re-treatment with S-1.Chest CT showed that ILD symptoms worsened compared with the previous week.After multidisciplinary consultation and correlation analysis,the patient was diagnosed with S-1-induced ILD.S-1 was discontinued before methylprednisolone and ventilator-assisted ventilation were used.The patient’s clinical symptoms and chest CT findings gradually improved.Conclusion Although S-1-induced ILD is rare,it may lead to severe respiratory failure and is even life-threatening.Clinicians should be alert to the risk of adverse drug reactions and conduct a safety assessment before prescribing S-1.Related examinations should be completed soon after patients develop such symptoms as fever or dyspnea.If S-1-induced ILD is considered likely,clinicians should adopt the right treatment regimen according to the ILD grade to improve the patient’s prognosis.
作者
孟德辉
王超
李华
丁春雷
MENG Dehui;WANG Chao;LI Hua;DING Chunlei(Department of Pharmacy,Beijing Arion Cancer Center,Beijing 100176,China;Breast Cancer Center,Beijing Arion Cancer Center,Beijing 100176,China)
出处
《中国药物警戒》
2026年第2期207-209,共3页
Chinese Journal of Pharmacovigilance
关键词
替吉奥
甲泼尼龙
间质性肺炎
胃癌
药品不良反应
Tegafur Gimeracil Oteracil Potassium
Methylprednisolone
Interstitial Lung Disease
Gastric Cancer
Adverse Drug Reactions
